| 引用本文: | 刘强,邓华聪,何辉,刘瑾瑜,周礼,李永玲.银丹心脑通软胶囊对2型糖尿病患者血小板活化因子、血液流变学和血管内皮细胞功能的影响[J].中国现代应用药学,2015,32(1):86-89. |
| LIU Qiang,DENG Huacong,HE Hui,LIU Jinyu,ZHOU Li,LI Yongling.Effects of Yindan Xinnaotong Capsule on Platelet Activating Factors, Blood Rheology and Endothelial Function in Patients with Type 2 Diabetes Mellitus[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(1):86-89. |
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| 摘要: |
| 目的 探讨银丹心脑通软胶囊对2型糖尿病患者血小板活化因子、血液流变学和血管内皮细胞功能的影响。方法 按随机数字表法将104例2型糖尿病患者分成对照组(51例)及治疗组(53例)。2组均控制饮食等基础上给予降糖治疗，使血糖持续达标，治疗组在此基础上加用银丹心脑通软胶囊(每次1.2 g，3次·d-1)连续治疗12周。比较2组患者治疗前后血小板膜糖蛋白PAC-1、CD62p表达，血液流变学指标和血浆NO、ET-1水平的变化。结果 与治疗前比较，治疗后，治疗组血小板膜糖蛋白PAC-1、CD62p和血液流变学各项指标及血浆ET-1均明显下降(P<0.05)，血浆NO显著升高(P<0.05)，且明显优于对照组治疗后(P<0.05)；而对照组治疗前后上述指标变化不显著。结论 银丹心脑通软胶囊可以抑制血小板活化，降低血液黏稠度，升高NO和降低ET-1的水平，从而改善糖尿病患者血管内皮细胞功能。 |
| 关键词: 银丹心脑通软胶囊 2型糖尿病 血小板活化 血液流变学 血管内皮功能 |
| DOI： |
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| 基金项目:国家自然科学基金项目(30771038) |
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| Effects of Yindan Xinnaotong Capsule on Platelet Activating Factors, Blood Rheology and Endothelial Function in Patients with Type 2 Diabetes Mellitus |
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LIU Qiang1, DENG Huacong2, HE Hui1, LIU Jinyu1, ZHOU Li1, LI Yongling3
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1.Department of Endocrinology, the Seven People’s Hospital of Chengdu, Chengdu 610041, China;2.Department of Endocrinology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;3.Department of Endocrinology, Sichuan Provincial People’s Hospital, Chengdu 610072, China
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| Abstract: |
| OBJECTIVE To investigate the effects of Yindan Xinnaotong capsule on platelet activating factors, blood rheology and endothelial function in patients with type 2 diabetes mellitus. METHODS A total of 104 patients with type 2 diabetes mellitus were randomly arranged into the two groups, receiving glucose-lowing drug only(control group, 51 cases) or glucose-lowing drug plus with Yindan Xinnaotong capsule(treatment group, 53 cases) respectively. The therapeutic course for all were 12 weeks. The expression of membrane glycoprotein PAC-1 and CD62p, the parameters of blood rheology, NO and ET-1 were detected in 2 groups before and after treatment. RESULTS Compared with before treatment, the expression of platelet membrane glycoprotein PAC-1 and CD62p, the parameters of blood rheology and ET-1 were significantly lower (P<0.05), NO were significantly higher in the treatment group(P<0.05), meanwhile the changes of datas in the treatment group were more significantly than those in the control group(P<0.05). There was no significant differences of datas between before and after treatment in control group. CONCLUSION Yindan Xinnaotong capsule can decrease the platelet activation, blood viscosity, ET-1 and imcrease NO, and also improve the vascular endothelial function in patients with type 2 diabetes mellitus. |
| Key words: Yindan Xinnaotong capsule type 2 diabetes mellitus platelet activation blood rheology endothelial function |
