| 引用本文: | 徐翀,刘茜,赵辉,刘艳芳.尼索地平对单硝酸异山梨酯在小鼠体内组织分布的影响[J].中国现代应用药学,2015,32(1):46-49. |
| XU Chong,LIU Qian,ZHAO Hui,LIU Yanfang.Influence of Nisoldipine on Distribution of Isosorbide-5-mononitrate in Mice Tissue[J].Chin J Mod Appl Pharm(中国现代应用药学),2015,32(1):46-49. |
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| 摘要: |
| 目的 考察尼索地平对单硝酸异山梨酯在小鼠体内组织分布的影响。方法 30只健康昆明种小鼠，♂，随机分成2组，分别为单独给药组和联合给药组，HPLC测定组织中单硝酸异山梨酯的浓度。结果 小鼠组织中单硝酸异山梨酯浓度在给药后0.083 h为小肠>胃>心>肝>肾，给药后0.5 h为胃>小肠>肾>心>肝。胃中最大浓度出现时间因给药方案不同而异：单独给药组在给药后0.5 h单硝酸异山梨酯浓度最大，联合给药组在给药后0.083 h浓度最大。胃中单硝酸异山梨酯最大浓度，2组具有显著性差异(P<0.05)。结论 尼索地平对单硝酸异山梨酯在小鼠组织中的分布具有一定影响。 |
| 关键词: 单硝酸异山梨酯 尼索地平 组织分布 高效液相色谱法 |
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| Influence of Nisoldipine on Distribution of Isosorbide-5-mononitrate in Mice Tissue |
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XU Chong1, LIU Qian2, ZHAO Hui2, LIU Yanfang2
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1.Department of Pharmacy, the First Hospital of China Medical University, Shenyang 110001, China;2.School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
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| Abstract: |
| OBJECTIVE To investigate the influence of nisoldipine on distribution of isosorbide-5-mononitrate in mice tissue. METHODS Healthy male mice were divided into isosorbide-5-mononitrate group and isosorbide-5-mononitrate combined with nisoldipine group. The content of isosorbide-5-mononitrate in tissues was detected by HPLC. RESULTS Tissue concentrations of isosorbide-5-mononitrate at 0.083 h post-dosing were in the order of small intestine＞stomach＞heart＞liver＞kidney, and stomach＞small intestine＞kidney＞heart＞liver at 0.5 h post-dosing. The highest concentration time of isosorbide-5- mononitrate in stomach was 0.083 h after combined administration; the highest concentration time of isosorbide-5-mononitrate in stomach was 0.5 h after single administration. There were significant differences in highest concentrations of isosorbide-5- mononitrate in stomach of 2 groups(P<0.05). CONCLUSION Nisoldipine has some influence on distribution of isosorbide-5- mononitrate in mice tissue. |
| Key words: isosorbide-5-mononitrate nisoldipine tissue distribution HPLC |
