1例华法林抵抗患者原因分析及药学监护

李波霞; 徐航<sup>*</sup>; 魏玉辉; 武新安

引用本文:	李波霞,徐航,魏玉辉,武新安.1例华法林抵抗患者原因分析及药学监护[J].中国现代应用药学,2014,31(10):1282-1283,1296.
	LI Boxia,XU Hang,WEI Yuhui,WU Xin’an.A Case Report: Analysis of Warfarin Resistance Cause and Pharmaceutical Care[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(10):1282-1283,1296.

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1例华法林抵抗患者原因分析及药学监护
李波霞¹, 徐航², 魏玉辉¹, 武新安¹
1.兰州大学第一医院药剂科，兰州 730000;2.南京大学医学院附属鼓楼医院药学部，南京 210008

摘要:

目的为临床药师发现华法林抵抗患者并参与其药学监护提供参考。方法基于基因检测结果为1例华法林抵抗患者制定抗凝方案，并对产生抵抗原因进行分析，详细描述临床药师如何实施药学监护的全过程。结果该患者出院后INR值达到目标范围，及时避免了出血事件的发生。结论对于华法林抵抗患者，临床药师尤其要注意及时发现，保持对患者长期随访及药学监护。

关键词: 临床药师华法林抵抗基因多态性药学监护

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A Case Report: Analysis of Warfarin Resistance Cause and Pharmaceutical Care

LI Boxia¹, XU Hang², WEI Yuhui¹, WU Xin’an¹

1.Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou 730000, China;2.Department of Pharmacy, Drum Tower Hospital Affiliated to Nanjing University Medical School, Nanjing 210008, China

Abstract:

OBJECTIVE To provide reference for clinical pharmacists discovering and participating in pharmaceutical care for warfarin resistance patients. METHODS Based on gene detection, the anticoagulation plan was built and the reason inducing warfarin resistance was analyzed. The process of pharmaceutical care by clinical pharmacist was described in details. RESULTS INR of the patient achieved the target area and hemorrhage events were avoided post-discharge. CONCLUSION For warfarin resistance patients, clinical pharmacists particularly need to discover in time and keep long term follow-up and pharmaceutical care.

Key words: clinical pharmacists warfarin resistance gene polymorphism pharmaceutical care