扑热息痛肝毒性中炎症反应的研究进展

李会英; 潘家琪; 汤治元<sup>*</sup>

引用本文:	李会英,潘家琪,汤治元.扑热息痛肝毒性中炎症反应的研究进展[J].中国现代应用药学,2014,31(6):763-767.
	LI Huiying,PAN Jiaqi,TANG Zhiyuan.Progress of Inflammation in Liver Toxicity Caused by Acetaminophen[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(6):763-767.

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扑热息痛肝毒性中炎症反应的研究进展
李会英¹, 潘家琪², 汤治元²
1.宁波大学医学院附属医院，浙江宁波 315020;2.宁波大学医学院，浙江宁波 315211

摘要:

扑热息痛(N-acetyl-para-aminophenol，APAP)是临床应用最广泛的解热镇痛药；作为肝毒性工具药物，APAP也被广泛用于药物肝毒性机制研究和测试药物的护肝潜力。炎症是加重细胞损伤的一个潜在因素，也能限制细胞损伤，清除细胞碎片和促进再生。30余年来，APAP肝毒性机制的研究和讨论一直在持续。笔者针对APAP肝毒性中的细胞内事件，尤其是与炎症反应、炎症介质、炎症细胞之间的关系进行综述，为临床应用和毒性机制研究提供参考。

关键词: 扑热息痛肝毒性炎症

DOI：

分类号:R969

基金项目:国家自然科学基金项目(81273582)；宁波市自然科学基金项目(2012A610211)

Progress of Inflammation in Liver Toxicity Caused by Acetaminophen

LI Huiying¹, PAN Jiaqi², TANG Zhiyuan²

1.The Affiliated Hospital of Medical College of Ningbo University, Ningbo 315020, China;2.Medical School of Ningbo University, Ningbo 315211, China

Abstract:

As the most widely used antipyretic analgesic, acetaminophen has been widely used as a model drug to study mechanisms of chemical-induced liver toxicity and test hepato-protective potential of new drugs. Inflammation may aggravate cell damage, by limiting cell injury, removing cell debris and promoting regeneration. The mechanisms of AAP-induced liver cell injury have been extensively investigated and discussed for more than 30 years. This review focuses on the intracellular events of acetaminophen-induced hepatotoxicity, particularly the relevance of the inflammatory response, inflammatory mediators and inflammatory cells, to help improve clinical application and lay a good basis for mechanism investigation.

Key words: acetaminophen hepatotoxicity inflammation