| 引用本文: | 徐懋琳,许雅妮,叶琳,孙晓译.冬凌草甲素靶向给药系统研究进展[J].中国现代应用药学,2014,31(8):1031-1036. |
| XU Maolin,XU Yani,YE Lin,SUN Xiaoyi.Advances in Oridonin Targeted Drug Delivery System[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(8):1031-1036. |
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| 摘要: |
| 目的 介绍冬凌草甲素靶向制剂的研究现状。方法 综述近年来国内外相关研究，介绍靶向制剂靶向原理和特性、药动药效学研究进展，并对其可行性和前景进行分析。结果 冬凌草甲素靶向制剂不仅可以提高冬凌草甲素的溶解度，而且提高了靶部位药物浓度，增强抗肿瘤效果、降低不良反应。结论 开发更高靶向效率、安全、经济、多类型的给药系统是未来冬凌草甲素靶向制剂的研究焦点。 |
| 关键词: 冬凌草甲素 靶向 抗肿瘤 |
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| 基金项目:浙江省卫生厅科研基金(2012KYA067)；浙江省自然科学基金(LQ12H30004) |
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| Advances in Oridonin Targeted Drug Delivery System |
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XU Maolin, XU Yani, YE Lin, SUN Xiaoyi
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Medical College, Zhejiang University City College, Hangzhou 310015, China
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| Abstract: |
| OBJECTIVE To introduce the progress on the research in oridonin targeted delivery. METHODS The researches of both domestic and abroad were reviewed in recent years. The targeting principal, efficiency, pharmacokinetics as well as pharmacodynamics were summarized. Its feasibility and prospect in drug delivery system was analyzed. RESULTS Oridonin targeted drug delivery system not only improves the solubility of oridonin, but also accumulates the drug at targeted sites, increases the anti-tumor activity and decreases toxicity. CONCLUSION The future research will focus on the development of kinds of oridonin targeted drug delivery system with high targeting efficiency, safety and economic. |
| Key words: oridonin targeting anti-tumor |
