细胞色素P450与外源物的相互作用研究进展

赵春; 李银生<sup>*</sup>; 蒋美琳; 丛琳; 邱江平

引用本文:	赵春,李银生,蒋美琳,丛琳,邱江平.细胞色素P450与外源物的相互作用研究进展[J].中国现代应用药学,2014,31(8):1020-1024.
	ZHAO Chun,LI Yinsheng,JIANG Meilin,CONG Lin,QIU Jiangping.Advance of the Interaction between Cytochrome P450 and Xenobiotics[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(8):1020-1024.

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细胞色素P450与外源物的相互作用研究进展
赵春¹, 李银生¹, 蒋美琳¹, 丛琳^1,2, 邱江平¹
1.上海交通大学农业与生物学院，上海 200240;2.黑龙江八一农垦大学，黑龙江大庆 163000

摘要:

细胞色素P450酶是一种多功能酶系，它既参与外源物的生物转化，也与内源性物质的代谢有关，并且作为肝细胞药物代谢的主要酶系参与药物毒性的代谢灭活。由于P450酶结构、功能和基因调控的多样性，自其发现以来，该酶系的研究一直是毒理学研究中的一个热点。本文综述了P450与药物代谢相关的主要亚型及其与药物的相互作用，探讨了P450酶与外源物代谢之间的相互作用机制。

关键词: 细胞色素P450 外源物药物代谢抑制

DOI：

分类号:

基金项目:国家自然科学基金(31172360)

Advance of the Interaction between Cytochrome P450 and Xenobiotics

ZHAO Chun¹, LI Yinsheng¹, JIANG Meilin¹, CONG Lin^1,2, QIU Jiangping¹

1.School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai 200240, China;2.Heilongjiang Bayi Agricultural University, Daqing 163000, China

Abstract:

As a kind of multifunction enzyme system, CYP450 enzyme have extensive biological significances. It is related to biological transformation of xenobiotics and metabolism of endogenous substances, and also participates in the metabolic inactivation of drug toxicity as a major enzyme system of drug metabolism in hepatocyte. As the diversity of structure, function and gene regulation in P450 enzymes the research on it has been a hot spot in toxicology study since it was found. In this article, it is summarized the subtypes of CYP450 related to drug metabolism and the interactions with drugs, and discuss the interaction mechanism between P450 enzymes and the xenobiotics.

Key words: CYP450 xenobiotics metabolism inhibition