五味子乙素的药理作用及其分子机制的研究进展

梁婧; 侯海燕; 兰晓霞; 孙旸; 陈亚琼<sup>*</sup>

引用本文:	梁婧,侯海燕,兰晓霞,孙旸,陈亚琼.五味子乙素的药理作用及其分子机制的研究进展[J].中国现代应用药学,2014,31(4):506-510.
	LIANG Jing,HOU Haiyan,LAN Xiaoxia,SUN Yang,CHEN Yaqiong.Advance in Study on Pharmacological Effect and Molecular Mechanisms of Schisandrin B[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(4):506-510.

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五味子乙素的药理作用及其分子机制的研究进展
梁婧¹, 侯海燕¹, 兰晓霞², 孙旸¹, 陈亚琼¹
1.武警后勤学院附属医院，天津 300162;2.武警后勤学院，天津 300162

摘要:

五味子是木兰科植物五味子的干燥成熟果实，是著名的滋补性中药，习称“北五味子”。其单体活性成分五味子乙素具有保肝、抗炎、抗肿瘤及抗氧化等多种药理作用，临床广泛应用于肝病的防护与治疗、心脑血管疾病、多种神经退行病变等领域。现对五味子乙素的药理作用、安全性及生物利用度等相关国内外最新研究现状作一系统综述，为进一步研究、开发和合理应用五味子乙素提供参考。

关键词: 五味子五味子乙素药理作用分子机制安全性生物利用度研究进展

DOI：

分类号:

基金项目:国家自然科学基金资助项目(81273977)；天津市自然科学基金项目(12JCYBJC16200)

Advance in Study on Pharmacological Effect and Molecular Mechanisms of Schisandrin B

LIANG Jing¹, HOU Haiyan¹, LAN Xiaoxia², SUN Yang¹, CHEN Yaqiong¹

1.Affiliated Hospital of the Chinese People's Armed Police Force Logistics College, Tianjin 300162, China;2.The Chinese People's Armed Police Force Logistics College, Tianjin 300162, China

Abstract:

Schisandra, the dried ripe fruit of Schisandra chinesis (Turcz.) Baill, is a topic traditional Chinese medicine, often called "Schisandra chinesis". Its single active ingredient of schizandrin (Schisandrin B) has a variety of pharmacological effects, such as hepatoprotective, anti-inflammatory, anti-tumor, anti-oxidation and so on. The schizandrin is widely applied in liver protection and treatment, cardiovascular and cerebrovascular diseases, a variety of neurodegenerative diseases in clinical. Our paper make a systematic review of recent related research at home and abroad which study the pharmacological effects, safety and bioavailability of the schizandrin.

Key words: Schisandra chinesis (Turcz.) Baill schisandrin B pharmacological effect molecular mechanisms security bioavailability advance