| 引用本文: | 王彬彬,张晓兰,陈培丰.艾迪注射液治疗15例高凝状态结直肠癌的临床观察[J].中国现代应用药学,2014,31(4):475-477. |
| WANG Binbin,ZHANG Xiaolan,CHEN Peifeng.Clinical Observation on 15 Colorectal Cancer Patients in Blood Hypercolktive State Treated with Aidi Injection[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(4):475-477. |
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| 摘要: |
| 目的 观察艾迪注射液对血浆D-二聚体的干预作用，探讨其对结直肠癌患者高凝状态的影响。 方法 筛选30例D-二聚体异常升高的具有复发高危因素Dukes’B期以上的结直肠癌患者，随机分为对照组与治疗组，每组15例，均采用标准FOLFOX或XELOX方案化疗，治疗组联合使用艾迪注射液，在疗程前后用免疫比浊法测定血浆D-二聚体值。结果 对照组D-二聚体升高10例，降低5例，均值在治疗前后统计学无差异；治疗组D-二聚体升高3例，降低12例，均值在治疗前后差异有统计学意义(P<0.01)，并且2组D-二聚体降低率的差异具有统计学意义(P<0.05)，二者治疗前后D-二聚体的净效应之间差异有统计学意义(P<0.01)。结论 艾迪注射液可降低高凝状态结直肠癌患者的D-二聚体水平，化疗对结直肠癌患者的D-二聚体水平无显著影响。 |
| 关键词: D-二聚体 结直肠癌 艾迪注射液 高凝状态 |
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| 基金项目:浙江省教育厅科研项目(Y200805472) |
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| Clinical Observation on 15 Colorectal Cancer Patients in Blood Hypercolktive State Treated with Aidi Injection |
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WANG Binbin, ZHANG Xiaolan, CHEN Peifeng
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The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China
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| Abstract: |
| OBJECTIVE To explore the intervention effect of Aidi injection on blood hypercolktive state of 15 patients with advanced colorectal cancer by means of testing plasma D-dimer’s levels. METHODS Thirty cases with colorectal cancer with abnormal D-dimer values were randomly divided into control group and treatment group, 15 cases in each group, and treated with chemotherapy or Aidi injection combining chemotherapy separately. Their plasma D-dimer concentrations were measured by immunoturbidimetric assay before and after treatment. RESULTS D-dimer concentrations of 10 cases in control group rose, the others reduced. No significant difference was found before and after treatment. D-dimer concentrations of 3 cases in treatment group rose, the others reduced. A significant difference of mean was found before and after treatment(P<0.01). The rate of decline and the deviation values of D-dimer were statistically significant difference between two groups(P<0.05 and P<0.01). CONCLUSION Aidi injection can ameliorate D-dimer concentrations of large intestine patients in blood hypercolktive state. Chemotherapy does not influence the plasma D-dimer concentrations of patients with colorectal cancer. |
| Key words: D-dimer colorectal cancer Aidi injection blood hypercolktive state |
