| 摘要: |
| 目的 介绍托吡酯的研究背景和合成研究进展。方法 综合国内外报道的文献，阐述托吡酯的合成方法。结果 重点列出了关键中间体的合成方法以及酯化法、氨解法、催化氢化法和水解法4种托吡酯的合成方法，分析各方法特点。结论 氨解法是托吡酯合成方法的主要研究方向。 |
| 关键词: 托吡酯 合成 进展 |
| DOI： |
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| Progress in Synthesis of Topiramate |
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MIAO Yu1,2, GUAN Yongxia1,3
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1.Lunan Pharmaceutical Group Corporation, Linyi 276000, China;2.National Engeering and Technology Research Center of Chirality Pharmaceutical, Linyi 276000, China;3.National Mammalian Cells Efficiently Express Engineering Laboratory, Linyi 276000, China
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| Abstract: |
| OBJECTIVE To introduce the background and current synthesis progress of topiramate. METHODS To review both domestic and international published reports regarding the synthesis of topiramate. RESULTS Made a list of synthesis methods of a key intermediate and four synthesis methods of topiramate including esterification, ammonolysis, catalytic hydrogenation and hydrolyzation and analyzing characteristics of synthesis methods. CONCLUSION The method of ammonolysis provides us a main research direction for efficient synthesis topiramate. |
| Key words: topiramate synthesis progress |
