美洛西林钠化学结构的确证

黄琦; 贾沪宁

引用本文:	黄琦,贾沪宁.美洛西林钠化学结构的确证[J].中国现代应用药学,2013,30(4):383-387.
	HUANG Qi,JIA Huning.Chemical Structural Confirmation of Mezlocillin Sodium[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(4):383-387.

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美洛西林钠化学结构的确证
黄琦¹, 贾沪宁²
1.浙江科技学院生物与化学工程学院，杭州 310023;2.中国药科大学分析化学教研室，南京 211198

摘要:

目的建立美洛西林钠化学结构的确证方法。方法通过热分析(TA)、元素分析(EA)、紫外吸收光谱(UV)、红外吸收光谱(IR)、核磁共振(NMR)以及质谱(MS)等分析手段对美洛西林钠样品进行结构分析。结果证实了美洛西林钠的结构为(2S，5R，6R)-3,3-二甲基-6-[(2R)-[3-(甲磺酰基)-2-氧代-1-咪唑烷甲酰氨基]-2-苯乙酰氨基]-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸钠盐。结论该方法准确可行，可为美洛西林钠的生产和鉴定提供较全面的参考依据。

关键词: 美洛西林钠结构确证波谱分析

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Chemical Structural Confirmation of Mezlocillin Sodium

HUANG Qi¹, JIA Huning²

1.School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou 310023, China;2.Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 211198, China

Abstract:

OBJECTIVE To establish a method for the determination of the chemical structure of mezlocillin sodium. METHODS Thermal analysis(TA), elemental analysis(EA), ultraviolet absorption spectrum(UV), infrared Fourier transform spectroscopy(FT-IR), nuclear magnetic resonance(NMR) and mass spectrometry(MS) were adopted to analyze the chemical structure of mezlocillin sodium. RESULTS The chemical structure of mezlocillin sodium was (2S,5R,6R)-3,3-dimethyl-6- [[(R)-2-[(3-methylsulfonyl-2-oxo-imidazolidin-1-yl)carbonylamino]-2-phenyl-acetyl] amino]-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane -2-carboxylic acid sodium salt. CONCLUSION The result of the method is accurate, general and can provide a comprehensive reference for production and identification of mezlocillin sodium.

Key words: mezlocillin sodium structural confirmation spectrum analysis