| 引用本文: | 张丹丹,李文娜,梅文杰,黄燮南.以卟啉类衍生物为光敏剂的光动力疗法的靶点研究进展[J].中国现代应用药学,2013,30(4):445-449. |
| ZHANG Dandan,LI Wenna,MEI Wenjie,HUANG Xienan.Studies on the Target of Photodynamic Therapy with Porphyrin Derivatives as Photosensitizer[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(4):445-449. |
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| 摘要: |
| 目的 介绍以卟啉类衍生物为光敏剂的光动力学疗法(PDT)的靶点研究进展。方法 从光敏剂的分布特性、活性氧的产生与作用、PDT中细胞凋亡的线粒体途径方面阐明线粒体为卟啉类衍生物光动力反应的主要靶点。结论 卟啉类衍生物作为最常用的光敏剂，能选择性浓集于靶部位产生活性氧，从而导致靶细胞的破坏。目前越来越多报道表明，在PDT中线粒体可能是最主要的靶点。 |
| 关键词: 线粒体 卟啉 光动力疗法 细胞凋亡 |
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| 基金项目:贵州省科学技术基金项目(黔科合[2007]2226) |
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| Studies on the Target of Photodynamic Therapy with Porphyrin Derivatives as Photosensitizer |
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ZHANG Dandan1, LI Wenna1, MEI Wenjie2, HUANG Xienan1
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1.Zunyi Medical College, Zhuhai Campus, Zhuhai 519041, China;2.Guangdong Pharmaceutical University, School of Pharmacy, Guangzhou 510006, China
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| Abstract: |
| OBJECTIVE Introduce the studies progress on the target of photodynamic therapy (PDT) with porphyrin derivatives as photosensitizers. METHODS This article discussed the evidences of mitochondria as the target site in PDT with three lines of data: the distribution characters of porphyrin derivatives as the photosensitizers in the cell; reactive oxygen species, the mitochondrial pathway for cell apoptosis in PDT. RESULTS Porphyrin derivatives as the most common photosensitizers could selectively concentrated at the target cell to produce reactive oxygen species, which lead to the destruction of target cells. CONCLUSION About where is the PDT target site in the cell, there is no concensus in the early studies, but increasing studies found that mitochondria may be the main target in PDT. |
| Key words: mitochondria porphyrin photodynamic therapy cell apoptosis |
