| 引用本文: | 李芙蓉,吴瑶,黄学荪,朱海燕,许巧巧,张秀华.三元相图法研究更昔洛韦自微乳化释药系统处方[J].中国现代应用药学,2013,30(8):873-876. |
| LI Furong,WU Yao,HUANG Xuesun,ZHU Haiyan,XU Qiaoqiao,ZHANG Xiuhua.Preparation of Ganciclovir Self-microemulsifying System by Temary Phase Diagram Method[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(8):873-876. |
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| 摘要: |
| 目的 采用自微乳化技术，研究更昔洛韦自微乳化释药系统，探究其最佳处方配比。方法 通过溶解度实验对油相、表面活性剂、助表面活性剂进行选择，找到最佳组份；通过三元相图实验并结合乳液粒径的测定寻找出更昔洛韦最佳的处方配比。结果 更昔洛韦自微乳化处方油相为IPM，乳化剂为cremophor RH40，助乳化剂为PEG 400(1∶1.5∶1.5)。结论 初步成功地制备了更昔洛韦自微乳化释药系统。 |
| 关键词: 更昔洛韦 自微乳化释药系统 处方 三元相图 |
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| 基金项目:温州市社会发展科学研究项目(S20100046) |
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| Preparation of Ganciclovir Self-microemulsifying System by Temary Phase Diagram Method |
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LI Furong1, WU Yao2, HUANG Xuesun1, ZHU Haiyan1, XU Qiaoqiao1, ZHANG Xiuhua1
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1.The First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China;2.Wenzhou Medical College, Wenzhou 325000, China
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| Abstract: |
| OBJECTIVE To evaluate the optimum formulation for the self-emulsifying drug delivery systems of ganciclovir. METHODS The formulation of the self-emulsifying drug delivery system of ganciclovir was optimized by studying the pseudo-ternary phase diagram, the solubility, and particle size. Ganciclovir was successfully embedded in the SEDDS emulsion. RESULTS Ganciclovir preparation of self-microemulsion was oil phase of IPM, surfactant cremophor RH40, co-surfactant of PEG 400 (1∶1.5∶1.5). CONCLUSION The preliminary ganciclovir self-microemulsifying prepartion is successfully prepared. |
| Key words: ganciclovir self-microemulsifying drug delivery system formula pseudo-ternary phase diagram |
