| 引用本文: | 黄楚龙,王延东,曾夏芸,叶成添.利奈唑胺滴眼液在兔眼角膜内的药动学[J].中国现代应用药学,2012,29(10):935-938. |
| HUANG Chulong,WANG Yandong,ZENG Xiayun,YE Chengtian.Pharmacokinetics of Linezolid in Ocular Cornea of Rabbit[J].Chin J Mod Appl Pharm(中国现代应用药学),2012,29(10):935-938. |
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| 摘要: |
| 目的 探讨利奈唑胺滴眼液单次滴兔眼后在角膜中的药动学特征。方法 40只新西兰大白兔，局部滴入利奈唑胺滴眼液50 mL，采用高效液相色谱法测定兔眼角膜中利奈唑胺的药物浓度，用DAS 2.1.1软件计算药动学参数。结果 给药后0~120 h，利奈唑胺在兔眼角膜中的最高浓度为(58.62±15.48)μg·g-1，消除半衰期t1/2为(38.09±11.59)h，药时曲线下面积AUC0-t为(2 459.02±508.95)μg·h·g-1，AUC0-∞为(2 834.13±578.96)μg·h·g-1。结论 利奈唑胺滴眼液单次滴兔眼后在角膜中具有良好的药代动力学特征和组织通透性。 |
| 关键词: 利奈唑胺 滴眼液 兔 角膜 药动学 |
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| 基金项目:广东省部产学研合作引导项目(2010B090400081)；高明区科技三项费用项目(201015) |
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| Pharmacokinetics of Linezolid in Ocular Cornea of Rabbit |
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HUANG Chulong1, WANG Yandong1, ZENG Xiayun2, YE Chengtian1
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1.Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China;2.Guangdong Wholewin Technology.,Ltd, Foshan 528531, China
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| Abstract: |
| OBJECTIVE To study pharmacokinetics of linezolid in ocular cornea of rabbit after ocular instillation. METHODS Forty New England rabbits were topically applied 50 mL of linezolid eye drops. Ocular cornea was sampled at different intervals after drug instillation, and the drug levels were assayed by HPLC. The pharmacokinetics parameters were figured out by DAS 2.1.1 process. RESULTS The peak concentration of linezolid in cornea was (58.62±15.48)μg·g-1 in 0-120 h. The t1/2 was (38.09±11.59)h. The AUC0-t was (2 459.02±508.95)μg·h·g-1, and AUC0-∞ was (2 834.13±578.96)μg·h·g-1. CONCLUSION Linezolid has a good pharmacokinetics character and permeability in ocular cornea of rabbit. |
| Key words: linezolid eye drops rabbits cornea pharmacokinetics |
