| 引用本文: | 吴丽荣,黄丽英.四-(三氟乙烷氧基)空核酞菁的合成与光谱性质研究[J].中国现代应用药学,2011,28(13):1327-1330. |
| WU Lirong,HUANG Liying.Study on Synthesis and Spectral Properties of Tetra-trifluoroethoxy Substituted Metal-free Pathalocyanine[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(13):1327-1330. |
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| 摘要: |
| 目的 合成了一种新的化合物即四-(三氟乙烷氧基)空核酞菁(H2PcF)，并研究其光谱性质。方法 以4-硝基邻苯二腈和三氟乙醇为起始原料，通过亲核取代反应合成4-三氟乙烷氧基邻苯二腈；再利用醇锂法合成H2PcF，并通过熔点、红外、质谱、元素分析等进行表征；同时研究其光谱性质(包括紫外吸收光谱、荧光光谱)。结果 H2PcF的合成产率是34.7%，在可见光尤其是光动力治疗窗(600~800 nm)有较强的吸收，且具有很强的荧光性质和较高的荧光量子产率(φF=0.29)。结论 H2PcF具有良好的溶解性和光谱特性，在光电材料或光学治疗方面具有潜在的应用价值。 |
| 关键词: 三氟乙烷氧基 空核酞菁 合成 荧光量子产率 |
| DOI： |
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| 基金项目:福建省自然基金项目(2007J0095) |
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| Study on Synthesis and Spectral Properties of Tetra-trifluoroethoxy Substituted Metal-free Pathalocyanine |
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WU Lirong, HUANG Liying
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Pharmacy College of Fujian Medical University, Fuzhou 350004, China
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| Abstract: |
| OBJECTIVE To synthesis a new compound of tetra-trifluoroethoxy substituted metal-free phthalocyaninate(H2PcF) and study its spectral properties. METHODS Firstly, 4-(trifluoroethoxy) phthalonitrile was synthesized by using 4-nitrophthalonitrile and 2, 2, 2-trifluoroethanol as starting materials by nucleophilic substitution. Then, H2PcF was synthesized based on the precursor of 4-(trifluoroethoxy) phthalonitrile and characterized by melting point, IR, MS and elemental analysis. Its UV spectrum and fluorescence spectrum were also studied. RESULTS The yield of H2PcF was 34.7%, it exhibited intense absorption in the visible region spectrum, mainly in the phototherapeutic window (600-800 nm) and strong fluorescence wih high fluorescence quantum yield(φF=0.29). CONCLUSION H2PcF has shown potential application in photoelectric material or phototherapy filed due to its good solubility and spectral properties. |
| Key words: trifluoroethoxy metal-free phthalocyanine synthesis fluorescence quantum yield |
