| 引用本文: | 方海红,宋明芬,汪永光,闫盼,李静,施剑飞.DRD2、ANKK1与5-HTR2A基因多态性对利培酮所致急性锥体外系反应的影响[J].中国现代应用药学,2021,38(18):2250-2255. |
| Fang Haihong,Song Mingfen,Wang Yongguang,Yan Pan,Li Jing,Shi Jianfei.influence of DRD2, ANKK1 and 5-HTR2A gene polymorphisms on extrapyramidal symptoms induced by risperidone[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(18):2250-2255. |
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| DRD2、ANKK1与5-HTR2A基因多态性对利培酮所致急性锥体外系反应的影响 |
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方海红1, 宋明芬2, 汪永光3, 闫盼2, 李静2, 施剑飞1,4
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1.安徽医科大学精神卫生与心理科学学院, 合肥 230032;2.杭州市第七人民医院分子生物学实验室, 杭州 310013;3.杭州市第七人民医院脑功能研究室, 杭州 310013;4.杭州市第七人民医院精神科, 杭州 310013
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| 摘要: |
| 目的 探讨多巴胺D2受体（dopamine receptor 2，DRD2）、锚蛋白重复序列和激酶结构域包含1（ankyrin repeat and kinase domain containing 1，ANKKl）以及5-羟色胺2A受体（5-hydroxytryptamine receptor 2A，5-HTR2A）基因多态性是否影响利培酮所致急性锥体外系反应。方法 入组单用利培酮4~6 mg的精神分裂症住院患者101例，服药4周，采用不良反应量表评定药物锥体外系反应，肌张力障碍、震颤、静坐不能、扭转性痉挛4个维度中，任1项严重程度评分≥2分，视为发生急性锥体外系反应。使用多重高温连接酶检测反应技术（iMLDR）检测DRD2（rs1799978、rs6275）、ANKK1（rs1800497）以及5-HTR2A （rs6311、rs7997012）基因多态性；分别采用χ2检验和logistic逐步回归分析基因多态性对利培酮所致锥体外系反应发生的影响。结果 χ2检验显示，rs7997012（χ2=4.98，P=0.026）对利培酮所致急性锥体外系发生的影响具有统计学意义，logistic回归显示rs1800497（P=0.038，OR=0.327，95%CI：0.144~0.938）与rs7997012（P=0.050，OR=0.410，95% CI：0.168~1.002）基因多态性对利培酮所致急性锥体外系反应发生的影响有统计学意义，并且2个基因多态性之间存在相互影响。本研究中未发现rs1799978、rs6275、rs6311与利培酮所致锥体外系反应相关。结论 ANKK1（rs1800497）与5-HTR2A （rs7997012）基因多态性对利培酮所致急性锥体外系反应有影响，并且5-HTR2A （rs7997012）与ANKK1（rs1800497）基因多态性的不同组合对利培酮所致急性锥体外系的发生影响不同。 |
| 关键词: 利培酮 急性锥体外系反应 基因多态性 DRD2 ANKK1 5-HTR2A |
| DOI：10.13748/j.cnki.issn1007-7693.2021.18.010 |
| 分类号:R969.3 |
| 基金项目:浙江省科技计划项目（2015C03054）；杭州市医药卫生科技重点项目（ZD20200078）；浙江省医药卫生科技计划项目（2020KY2222，2020KY744） |
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| influence of DRD2, ANKK1 and 5-HTR2A gene polymorphisms on extrapyramidal symptoms induced by risperidone |
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Fang Haihong1, Song Mingfen2, Wang Yongguang3, Yan Pan2, Li Jing2, Shi Jianfei1,4
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1.School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei 230032, China;2.Hangzhou Seventh People's Hospital, Molecular Biological Laboratory, Hangzhou 310013, China;3.Hangzhou Seventh People's Hospital, Department of Brain Functioning Research, Hangzhou 310013, China;4.Hangzhou Seventh People's Hospital, Department of Psychiatry, Hangzhou 310013, China
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| Abstract: |
| OBJECTIVE To investigate whether DRD2, ANKK1 and 5-HTR2A genetic polymorphisms could influence acute extrapyramidal symptoms induced by risperidone. METHODS A total of 101 schizophrenic patients, treated with risperidone alone at the dose of 4-6 mg for 4 weeks, were recruited. Treatment Emergent Symptom Scale (TESS) was used to evaluate extrapyramidal symptoms. The score ≥ 2 in any dimension of dystonia, tremor, akathisia or torsion dystonia was regarded as the occurrence of acute extrapyramidal symptoms. iMLDR (improved multiple ligase detection reaction) was performed to detect the genetic polymorphisms of DRD2(rs1799978, rs6275), ANKK1(rs1800497) and 5-HTR2A(rs6311, rs7997012). Chi-square test and multivariate logistic stepwise regression analysis were run to estimate the effects of DRD2, ANKK1, 5-HTR2A genetic polymorphisms on acute extrapyramidal symptoms induced by risperidone. RESULTS Chi-square test showed that rs7997012 significantly influenced the occurrence of acute extrapyramidal system(χ2=4.98, P=0.026). Logistic analysis demonstrated that rs1800497(P=0.038, OR=0.327, 95%CI:0.144-0.938) and rs7997012(P=0.050, OR=0.410, 95%CI:0.168-1.002) genetic polymorphisms had a statistical significance on the occurrence of acute extrapyramidal reaction in an interaction manner. Our present study did not find any correlation of rs1799978, rs6275, rs6311 with acute extrapyramidal reaction of risperidone. CONCLUSION The ANKK1 and 5-HTR2A genetic polymorphisms maybe associated with the occurrence of acute extrapyramidal symptoms induced by risperidone. And this association may differ from the different combinations of their genotypes. |
| Key words: risperidone acute extrapyramidal symptoms gene polymorphisms DRD2 ANKK1 5-HTR2A |
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