| 引用本文: | 许杜娟,刘萌芽,蔡邦荣,刘改枝.穿心莲内酯对神经退行性疾病的作用及其机制研究进展[J].中国现代应用药学,2021,38(11):1383-1388. |
| XU Dujuan,LIU Mengya,CAI Bangrong,LIU Gaizhi.Research Progress on Effect and Mechanism of Andrographolide on Neurodegenerative Disease[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(11):1383-1388. |
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| 摘要: |
| 氧化应激、线粒体功能障碍以及炎症反应是神经退行性疾病如阿尔兹海默病（Alzheimer’s disease，AD）和帕金森病（Parkinson’s disease，PD）等发生和发展的关键环节。因此，保护线粒体、缓解氧化应激和抑制炎症对防治此类疾病具有重要意义。穿心莲内酯是穿心莲的主要有效成分，具有较好的抗炎、抗肿瘤、抗病毒、抗HIV和保肝等生物活性。近年来，越来越多研究证实穿心莲内酯在神经退行性疾病方面有着良好的应用前景，主要通过诱导线粒体自噬而保护线粒体稳态、抑制炎症小体的活化；清除活性氧，保护线粒体，或抑制小胶质细胞炎症反应保护神经元细胞。文章总结了近十年来穿心莲内酯在神经退行性疾病如AD、PD和脑缺血损伤等方面的药理活性及机制研究，以期为穿心莲内酯的研究开发和在神经退行性疾病中的临床应用提供参考。 |
| 关键词: 穿心莲内酯 神经退行性疾病 药理活性 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.11.019 |
| 分类号:R965.1 |
| 基金项目:国家自然科学基金青年基金项目（81803740）；中国博士后科学基金（2020M682311）；河南省科技攻关项目（202102310514） |
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| Research Progress on Effect and Mechanism of Andrographolide on Neurodegenerative Disease |
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XU Dujuan1,2, LIU Mengya1, CAI Bangrong1, LIU Gaizhi1
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1.College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China;2.Yanshi Traditional Chinese Medicine Hospital, Luoyang 471900, China
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| Abstract: |
| Oxidative stress, mitochondrial dysfunction and neuroinflammation have been considered as key link in the occurrence and development of the neurodegenerative diseases such as Alzheimer’s disease(AD) and Parkinson’s disease(PD). It is of great significance to protect mitochondria, relieve oxidative stress and inhibite neuroinflammation in the prevention and treatment of neurodegenerative diseases. Andrographolide is the main effective component of andrographolide, exhibiting anti-inflammatory, anti-tumor, antiviral, anti-HIV, liver protection and others. More and more studies have proved that andrographolide is a promising potential drug candidate against neurodegenerative disorders, and its mechanism of action involves in protection of mitochondrial homeostasis by mitophagy, inhibiting the inflammasome activation and microglia mediated neuroinflammation as well as elimination of reactive oxygen species(ROS). This paper systemically review the progress on the pharmacological activity and mechanism of andrographolide in AD, PD and cerebral ischemia in the last ten years, expecting to provide references on the biological studies and clinic translation of AG for neurodegenerative disorders. |
| Key words: andrographolide neurodegenerative diseases pharmacological activity |
