提高中药固体制剂载药量的意义与途径

董育瑄; 王妍; 洪燕龙; 林晓; 鲜洁晨; 赵立杰; 吴飞; 王优杰

引用本文:	董育瑄,王妍,洪燕龙,林晓,鲜洁晨,赵立杰,吴飞,王优杰.提高中药固体制剂载药量的意义与途径[J].中国现代应用药学,2024,41(3):420-427.
	DONG Yuxuan,WANG Yan,HONG Yanlong,LIN Xiao,XIAN Jiechen,ZHAO Lijie,WU Fei,WANG Youjie.Significance and Approach of Increasing Drug Loading in Solid Preparation of Traditional Chinese Medicine[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(3):420-427.

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提高中药固体制剂载药量的意义与途径
董育瑄¹, 王妍¹, 洪燕龙², 林晓³, 鲜洁晨¹, 赵立杰¹, 吴飞¹, 王优杰¹
1.上海中医药大学中药现代制剂技术教育部工程研究中心，上海 201203;2.上海中医药大学中医健康服务协同创新中心，上海 201203;3.上海中医药大学中药学院，上海 201203

摘要:

载药量是评价中药固体制剂产品质量的重要指标。载药量受药物特性、剂型、工艺、体内递药的制约，影响制剂成型工艺、治疗效果以及药物释放速率。通过查阅国内外文献，本文提出了提高载药量可以提高患者的顺应性，降低生产成本，降低辅料引入的风险等意义。综述了提高载药量的可行途径，如选择高效能辅料，适合的药物制备技术，修饰药物的物理性质等，以期为高载药量，高品质制剂的开发提供理论依据。

关键词: 载药量载药体中药制剂患者依从性药辅合一

DOI：10.13748/j.cnki.issn1007-7693.20224135

分类号:R283.6

基金项目:上海市自然科学基金项目(20ZR1458400，23ZR1463500)

Significance and Approach of Increasing Drug Loading in Solid Preparation of Traditional Chinese Medicine

DONG Yuxuan¹, WANG Yan¹, HONG Yanlong², LIN Xiao³, XIAN Jiechen¹, ZHAO Lijie¹, WU Fei¹, WANG Youjie¹

1.Shanghai University of Traditional Chinese Medicine, Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine, Ministry of Education, Shanghai 201203, China;2.Shanghai University of Traditional Chinese Medicine, Traditional Chinese Medicine Health Service Collaborative Innovation Center, Shanghai 201203, China;3.Shanghai University of Traditional Chinese Medicine, School of Pharmacy, Shanghai 201203, China

Abstract:

Drug loading is an important index to evaluate the quality of solid preparation of traditional Chinese medicine. Drug loading is restricted by drug characteristics, dosage form, process, and drug delivery in vivo, which affects the preparation process, therapeutic effect, and drug release rate. By consulting domestic and foreign literature, this paper put forward the significance of increasing the drug loading: improving the compliance of patients, reducing the production cost, reducing the risk of the excipients. In this review, the possible approaches to increase drug loading, such as the selection of high-efficiency excipients, suitable drug preparation techniques, and modification of the physical properties of drugs are summarized. It will provide theoretical basis through this review for the development of high drug loading and high-quality formulations.

Key words: drug loading drug carrier traditional Chinese medicine preparations compliance of patients unification of medicines and excipients