| 引用本文: | 宝钢,图诺木拉,朝格巴达拉夫,苏达毕力格,何陈林,敖敦格日乐,其日格尔,拉喜那木吉拉.蒙药材蓝玉簪龙胆的化学成分研究[J].中国现代应用药学,2024,41(1):27-32. |
| Baogang,Tunuomula,Chaogebadalafu,Sudabilige,HE Chenlin,Aodungerile,Qirigeer,Laxinamujila.Study on Chemical Constituents of Mongolian Medicinal Material Gentiana Veitchiorum[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(1):27-32. |
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| 蒙药材蓝玉簪龙胆的化学成分研究 |
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宝钢1, 图诺木拉1, 朝格巴达拉夫1, 苏达毕力格1, 何陈林1, 敖敦格日乐1,2, 其日格尔1,2, 拉喜那木吉拉1,2
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1.内蒙古民族大学蒙医药学院，国家药品监督管理局中药(蒙药)质量控制重点实验室，内蒙古 通辽 028000;2.蒙医药研发工程教育部重点实验室，内蒙古 通辽 028000
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| 摘要: |
| 目的 研究蒙药材蓝玉簪龙胆的化学成分。方法 采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱以及制备型HPLC等色谱手段进行分离纯化，并通过波谱数据和理化常数鉴定化合物结构。结果 从蓝玉簪龙胆花中分离得到10个化合物，化合物分别鉴定为2,3-二羟基苯甲醇β-吡喃葡萄糖苷(1)、龙胆苦苷(2)、2’-(O, m-Dihydroxybenzoyl) sweroside(3)、异荭草素(4)、异荭草素-3’-甲基醚(5)、异牡荆苷(6)、异荭草素-4’-O-吡喃葡萄糖苷(7)、异肥皂草苷(8)、熊果酸(9)、β-谷甾醇(10)。结论 化合物1为新的苄醇糖苷类化合物，化合物10为首次从该植物中分离得到。 |
| 关键词: 蒙药材 蓝玉簪龙胆 哈日-珠勒根-其木格 化学成分 |
| DOI：10.13748/j.cnki.issn1007-7693.20221779 |
| 分类号:R285.5 |
| 基金项目:内蒙古自治区卫生健康科技计划项目(202202258)；内蒙古自治区草原英才项目(CYYC21003) |
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| Study on Chemical Constituents of Mongolian Medicinal Material Gentiana Veitchiorum |
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Baogang1, Tunuomula1, Chaogebadalafu1, Sudabilige1, HE Chenlin1, Aodungerile1,2, Qirigeer1,2, Laxinamujila1,2
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1.College of Mongolian Medicine, Inner Mongolia Minzu University, NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Mongolian Medicine, Tongliao 028000, China;2.Key Laboratory of Mongolian Medicine Research and Development Engineering, Ministry Education, Tongliao 028000, China
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| Abstract: |
| OBJECTIVE To research the chemical components of Mongolian medicinal material Gentiana veitchiorum. METHODS Separation and purification were conducted using silica gel column chromatography, Sephadex LH-20 gel column chromatography, and preparative HPLC, and the compound structure was identified through spectral data and physicochemical constants. RESULTS Ten compounds were obtained from the separation of Gentiana veitchiorum. The compounds were respectively authenticated as 2,3-dihydroxybenzyl alcohol β-glucopyranoside(1), gentiopicroside(2), 2'-(O, m-Dihydroxybenzoyl) sweroside(3), isoorientin(4), isoorientin-3'-methyl ether(5), isovitexin(6), isoorientin-4’-O-glucopyranoside(7), isosoapin(8), ursolic acid(9), β-Sitosterol(10). CONCLUSION The compound 1 is authenticated as the new benzyl alcohol glycoside. The compound 10 is firstly separated from this medicinal plant. |
| Key words: Mongolian medicinal materials Gentiana veitchiorum Hari-Zhulegen-Qimuge chemical constituents |
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