| 引用本文: | 刘奇,章越,盛燕,胡云莉,姜慧洁,慎凯峰,姜艳,陈承守,周丹英.基于层次分析法-熵权法-独立性权法结合正交设计法优选胃病1号提取工艺[J].中国现代应用药学,2023,40(21):2998-3004. |
| LIU Qi,ZHANG Yue,SHENG Yan,HU Yunli,JIANG Huijie,SHEN Kaifeng,JIANG Yan,CHEN Chengshou,ZHOU Danying.Optimization of Extraction Process of Gastropathy Oral Thick Paste 1 by Orthogonal Design Based on Analytic Hierarchy Process Method–Entropy Weight Method-Independent Weight Method[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(21):2998-3004. |
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| 基于层次分析法-熵权法-独立性权法结合正交设计法优选胃病1号提取工艺 |
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刘奇1, 章越1, 盛燕2, 胡云莉1, 姜慧洁1, 慎凯峰1, 姜艳1, 陈承守3, 周丹英1
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1.浙江省中药研究所有限公司, 杭州 310023;2.浙江省药品化妆品审评中心, 杭州 310012;3.浙江渭宝药业有限公司, 杭州 310013
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| 摘要: |
| 目的 确定指标权重，优选胃病1号的提取工艺。方法 以加水量、提取时间和提取次数为考察因素，在单因素试验考察基础上，选择L9(34)正交表设计实验，采用HPLC测定绿原酸含量，紫外分光光度法测定总黄酮含量，以上述两者含量外加干浸膏得率为评价指标，基于层次分析法-熵权法-独立性权法赋权来权重多指标综合评分，结合正交试验设计，优选最佳提取工艺。结果 经权重后多指标评分更加科学合理，最终优选的胃病1号提取工艺条件为加8倍量水，提取2次，每次0.5 h。结论 采用层次分析法-熵权法-独立性权法优选的提取工艺合理、可行，工艺稳定可行，重复性好，适用于胃病1号的制备，为后续研发提供参考。 |
| 关键词: 胃病1号 提取工艺 层次分析法-熵权法-独立性权法 |
| DOI：10.13748/j.cnki.issn1007-7693.20230924 |
| 分类号:R283.6 |
| 基金项目:浙江省“尖兵”“领雁”研发攻关计划(2023C03039) |
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| Optimization of Extraction Process of Gastropathy Oral Thick Paste 1 by Orthogonal Design Based on Analytic Hierarchy Process Method–Entropy Weight Method-Independent Weight Method |
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LIU Qi1, ZHANG Yue1, SHENG Yan2, HU Yunli1, JIANG Huijie1, SHEN Kaifeng1, JIANG Yan1, CHEN Chengshou3, ZHOU Danying1
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1.Zhejiang Institute of Traditional Chinese Medicine Co., Ltd., Hangzhou 310023, China;2.Zhejiang Provincial Drug and Cosmetics Evaluation Center, Hangzhou 310012, China;3.Zhejiang Weibao Pharmaceutical Co., Ltd., Hangzhou 310013, China
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| Abstract: |
| OBJECTIVE To determine the index weight, optimize the extraction process of gastropathy oral thick paste 1. METHODS Taking the amount of water added, extraction time and extraction times as factors, depend on the single factor experiment, L9(34) orthogonal table was selected to design the experiment. The content of chlorogenic acid was determined by HPLC and the content of total flavonoids content was determined by ultraviolet spectrophotometry. With the above two contents plus the yield of dry extractum as the evaluation index, the weights were assigned based on the analytic hierarchy process, entropy weight method and independence weight method, and the extraction process was optimized by orthogonal experimental design. RESULTS Multi-index scoring was more scientific and reasonable, and the final optimal extraction conditions for gastropathy oral thick paste 1 were as follows: add 8 times the amount of water, extract twice and 0.5 h for each time. CONCLUSION The optimized extraction process using analytic hierarchy process, entropy weight method and independence weight method is reasonable, feasible, stable, and reproducible, which is suitable for the preparation of gastropathy oral thick paste 1, providing reference for subsequent research and development. |
| Key words: gastropathy oral thick paste 1 extraction technology analytic hierarchy process-entropy weight method- independent weight method |
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