| 引用本文: | 张宇轩,钱庆元,王芃,李晓琳,李茂星.提高低压低氧环境下红细胞氧亲和力的策略及潜在药物[J].中国现代应用药学,2023,40(16):2315-2328. |
| ZHANG Yuxuan,QIAN Qingyuan,WANG Peng,LI Xiaolin,LI Maoxing.Strategies and Potential Drugs to Improve Erythrocyte Oxygen Affinity in Hypobaric and Hypoxic Environment[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(16):2315-2328. |
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| 提高低压低氧环境下红细胞氧亲和力的策略及潜在药物 |
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张宇轩1,2, 钱庆元2,3, 王芃2, 李晓琳1,2, 李茂星1,3,4
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1.甘肃中医药大学药学院, 兰州 730000;2.联勤保障部队第九四〇医院全军高原医学实验室, 兰州 730050;3.兰州大学药学院, 兰州 730000;4.军事科学院军事医学研究院辐射医学研究所, 北京 100850
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| 摘要: |
| 目的 归纳和总结目前研究中能够在低压低氧环境下提高红细胞氧亲和力的策略及潜在的药物。方法 通过查阅CNKI数据库、Web of Science数据库及Pubmed数据库中有关低压低氧环境与红细胞氧亲和力关系的文献，对其进行筛选、提取和归纳总结。结果 低压低氧环境下，机体摄氧能力、氧气利用效率下降，导致机体处于缺氧状态。提高红细胞氧亲和力可帮助机体适应与习服低压低氧环境，且较多提高方式已在其他疾病中得到应用。结论 通过提高低压低氧环境下红细胞氧亲和力来提高氧气的利用率是目前预防高原低压低氧环境对人体损伤研究的起点与重点。 |
| 关键词: 低压 低氧 红细胞 血红蛋白 氧亲和力 |
| DOI：10.13748/j.cnki.issn1007-7693.20223471 |
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| 基金项目:后勤科研项目(CLB21J036)；拔尖培育项目(2021yxky001) |
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| Strategies and Potential Drugs to Improve Erythrocyte Oxygen Affinity in Hypobaric and Hypoxic Environment |
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ZHANG Yuxuan1,2, QIAN Qingyuan2,3, WANG Peng2, LI Xiaolin1,2, LI Maoxing1,3,4
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1.College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, China;2.The PLA Highland Medical Laboratory, The 940 th Hospital of Joint Logistic Support Force of Chinese People's Liberation Army, Lanzhou 730050, China;3.College of Pharmacy, Lanzhou University, Lanzhou 730000, China;4.Institute of Radiation Medicine Sciences, Academy of Military Medical, Academy of Military Sciences, Beijing 100850, China
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| Abstract: |
| OBJECTIVE To summarize the strategies and potential drugs that can improve the oxygen affinity of red blood cells in the hypobaric and hypoxic environment in the current research. METHODS The retrieved literatures were screened, extracted and summarized by referring to the literature on the relationship between hypobaric hypoxic environment and erythrocyte oxygen affinity in CNKI database, Web of Science database and Pubmed database. RESULTS Under the hypobaric and hypoxic environment, the body’s oxygen uptake capacity and oxygen utilization efficiency decreased, resulting in the body being in a state of hypoxia. Improving the oxygen affinity of red blood cells could help the body adapt to and get used to the hypobaric and hypoxic environment, and many improvement methods had been applied in other diseases. CONCLUSION Improving the oxygen utilization rate of red blood cells by increasing the oxygen affinity of erythrocytes under hypobaric and hypoxia environment is the starting point and focus of the current research on preventing the damage of high altitude hypobaric and hypoxic environment to the human body. |
| Key words: hypobaric hypoxia erythrocyte hemoglobin oxygen affinity |
