知母黄柏药对治疗糖尿病骨质疏松症的药效物质和作用机制研究进展

王芳; 邓雪慧; 许平翠; 林炳锋; 王娜妮<sup>*</sup>

引用本文:	王芳,邓雪慧,许平翠,林炳锋,王娜妮.知母黄柏药对治疗糖尿病骨质疏松症的药效物质和作用机制研究进展[J].中国现代应用药学,2023,40(21):3039-3046.
	WANG Fang,DENG Xuehui,XU Pingcui,LIN Bingfeng,WANG Nani.Research Progress on Pharmacodynamic Substances and Mechanism of Anemarrhenae Rhizoma- Phellodendri Chinensis Cortex Herb Pair in the Treatment of Diabetic Osteoporosis[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(21):3039-3046.

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知母黄柏药对治疗糖尿病骨质疏松症的药效物质和作用机制研究进展
王芳^1,2, 邓雪慧¹, 许平翠², 林炳锋², 王娜妮^1,2
1.浙江中医药大学, 杭州 311400;2.浙江省中医药研究院, 杭州 310007

摘要:

糖尿病骨质疏松症是由长期高血糖造成的全身代谢性骨病，已成为糖尿病的主要并发症之一，具有骨量减少、骨微结构破坏、骨脆性增加等特点。知母黄柏药对是一个经典中药配伍组合，在多数抗糖尿病骨质疏松症方剂中都有体现。现代药理研究表明，药对促进骨形成和抑制骨吸收的药效作用与Nrf2、MAPK、Wnt、RANK/RANKL信号通路及细胞自噬等密切相关。药对配伍能改变药效物质的溶出度和药动学，且药效物质有协同增效的作用。本文总结了知母黄柏药对的药效物质和抗糖尿病骨质疏松症作用机制，为该药对的进一步研究和开发提供参考。

关键词: 知母黄柏药对配伍糖尿病骨质疏松症药效物质

DOI：10.13748/j.cnki.issn1007-7693.20223030

分类号:R285

基金项目:国家自然科学基金项目(81973447)；浙江省自然科学基金项目(LY21H280001)；浙江省中医药科技计划项目(2021ZQ018)

Research Progress on Pharmacodynamic Substances and Mechanism of Anemarrhenae Rhizoma- Phellodendri Chinensis Cortex Herb Pair in the Treatment of Diabetic Osteoporosis

WANG Fang^1,2, DENG Xuehui¹, XU Pingcui², LIN Bingfeng², WANG Nani^1,2

1.Zhejiang Chinese Medical University, Hangzhou 311400, China;2.Zhejiang Academy of Traditional Chinese Medicine, Hangzhou 310007, China

Abstract:

Diabetic osteoporosis is a systemic metabolic bone disease caused by long-term hyperglycemia and has become one of the major complications of diabetes. It is characterized by decreased bone mass, destroyed bone microstructure, and increased bone fragility. Anemarrhenae Rhizoma-Phellodendri Chinensis Cortex herb pair is a classic drug combination, and has been widely used in many anti-diabetic osteoporosis prescriptions. The pharmacological studies have shown that the effects of this herb pair on promoting formation and inhibiting bone resorption are closely related to the Nrf2, MAPK, Wnt and RANK/RANKL signaling pathways as well as autophagy. The compatibility of this herb pair changes the dissolution and pharmacokinetics of the active substances, which have synergistic effects. This article summarized the effective substances of Anemarrhenae Rhizoma-Phellodendri Chinensis Cortex and its mechanism of action against diabetes and osteoporosis, providing a reference for further research and development of the drug pair.

Key words: Anemarrhenae Rhizoma Phellodendri Chinensis Cortex herb pair compatibility diabetic osteoporosis pharmacodynamic substance