Ca<sup>2+</sup>/CaM依赖性蛋白激酶II在心力衰竭中的作用机制及中医药治疗应用进展

柏婷燕; 易希善; 赵信科; 刘凯; 蒋虎刚; 李应东<sup>*</sup>

引用本文:	柏婷燕,易希善,赵信科,刘凯,蒋虎刚,李应东.Ca²⁺/CaM依赖性蛋白激酶II在心力衰竭中的作用机制及中医药治疗应用进展[J].中国现代应用药学,2023,40(14):2023-2031.
	BAI Tingyan,YI Xishan,ZHAO Xinke,LIU Kai,JIANG Hugang,LI Yingdong.Mechanism of Action of Ca²⁺/Calmodulin Dependent Protein Kinase II in Heart Failure and the Progress of Its Application in Traditional Chinese Medicine Treatment[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(14):2023-2031.

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Ca²⁺/CaM依赖性蛋白激酶II在心力衰竭中的作用机制及中医药治疗应用进展
柏婷燕¹, 易希善¹, 赵信科¹, 刘凯¹, 蒋虎刚¹, 李应东^1,2
1.甘肃中医药大学, 兰州 730000;2.甘肃中医药大学附属医院, 兰州 730000

摘要:

心力衰竭是一种常见的多发病，是各种心脏疾病发展的终末阶段，发病机制十分复杂，严重危害着人类健康。大量研究表明Ca²⁺/CaM依赖性蛋白激酶II(Ca²⁺/Calmodulin dependent protein kinase II，CaMKII)在心力衰竭的发生发展中起着重要的作用。中医药在防治心力衰竭方面具有独特优势和良好前景，其中有不少可靶向调节CaMKII的复方和中药有效成分。本文就CaMKII信号通路在衰竭心脏中的作用机制以及近年来中医药通过靶向调节CaMKII信号防治心力衰竭研究进展作主要阐述，以期为临床中医药防治心力衰竭方面提供参考意见并拓展思路。

关键词: 心力衰竭 CaMKII信号通路作用机制中医药研究进展

DOI：10.13748/j.cnki.issn1007-7693.20222695

分类号:R966

基金项目:甘肃省中医药防治重大疾病科研课题(GZKZD-2018-2)

Mechanism of Action of Ca²⁺/Calmodulin Dependent Protein Kinase II in Heart Failure and the Progress of Its Application in Traditional Chinese Medicine Treatment

BAI Tingyan¹, YI Xishan¹, ZHAO Xinke¹, LIU Kai¹, JIANG Hugang¹, LI Yingdong^1,2

1.Gansu University of Chinese Medicine, Lanzhou 730000, China;2.Affiliated Hospital of Gansu University of Chinese 1. Jining Medical University, Institute of Behavioral Medicine Education, 2. Jining Medical University, Institute of Precision Medicine, Jining 272067, China

Abstract:

Heart failure is a common frequently-occurring disease, and it is the terminal stage of the development of various heart diseases. The pathogenesis is very complex and seriously endangers human health. A large number of studies have shown that Ca²⁺/Calmodulin dependent protein kinase II(CaMKII) plays an important role in the occurrence and development of heart failure. Traditional Chinese medicine has unique advantages and good prospects in the prevention and treatment of heart failure. Among them, there are many compound and their active ingredients can target and regulate CaMKII. This paper mainly expounds the mechanism of the CaMKII signaling pathway in the failing heart and the research progress of traditional Chinese medicine in preventing and treating heart failure by targeting the regulation of CaMKII signaling in recent years, in order to provide reference and expand ideas for clinical traditional Chinese medicine prevention and treatment in heart failure.

Key words: heart failure CaMKII signaling pathway mechanism traditional Chinese medicine research progress