| 引用本文: | 王霞霞,安方玉,颜春鲁,孙柏,汪春梅,柳颖,石瑶,袁灵青,吕栋辉,赵延真.非编码RNA调控骨质疏松症骨重建机制及补肾壮骨类中医药治疗机制研究进展[J].中国现代应用药学,2023,40(17):2462-2472. |
| WANG Xiaxia,AN Fangyu,YAN Chunlu,SUN Bai,WANG Chunmei,LIU Ying,SHI Yao,YUAN Lingqing,LYU Donghui,ZHAO Yanzhen.Research Progress on the Mechanism of Non-coding RNA Regulation of Bone Reconstruction in Osteoporosis and the Therapeutic Mechanism of Traditional Chinese Medicine for Tonifying Kidney and Strengthening Bone[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(17):2462-2472. |
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| 非编码RNA调控骨质疏松症骨重建机制及补肾壮骨类中医药治疗机制研究进展 |
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王霞霞1, 安方玉1,2, 颜春鲁1,2,3, 孙柏1, 汪春梅1, 柳颖1, 石瑶1, 袁灵青1, 吕栋辉1, 赵延真1
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1.甘肃中医药大学, 兰州 730000;2.甘肃省中医药防治慢性疾病重点实验室, 兰州 730000;3.甘肃省中医药研究中心, 兰州 730000
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| 摘要: |
| 非编码RNA (non-coding RNAs，ncRNAs)是一种缺乏蛋白编码功能但可以影响染色体结构、基因转录及参与表观遗传调控的特殊RNA，主要包括长链非编码RNA、微小RNA等。近年来研究发现，这些ncRNAs主要通过影响骨质疏松(osteoporosis，OP)的骨吸收与骨形成来维持其骨重建。明确ncRNAs在OP发生发展中的调控机制可能是未来治疗OP药物药效筛选的关键靶点。由于中医将OP归属于“骨痹”范畴，根据中医的“肾主骨生髓”理论，临床主要采用补肾壮骨类方药来治疗OP，且疗效显著。已有研究发现，补肾壮骨类方药可通过上调或下调ncRNA的表达来增强成骨细胞增殖或抑制破骨细胞分化，最终维持了OP骨稳态，从而发挥疗效，但其具体分子机制仍处于探索阶段。故本文通过总结近年来补肾壮骨类方药通过调控ncRNAs治疗OP的分子机制，以期为治疗OP药物药效关键靶点的筛选和中医药防治OP提供新思路。 |
| 关键词: 中医药 补肾壮骨 骨质疏松 非编码RNA 骨重建 |
| DOI：10.13748/j.cnki.issn1007-7693.20222021 |
| 分类号: |
| 基金项目:国家自然科学基金项目(82060872)；甘肃省自然科学基金项目(20JR5RA185，21JR11RA138)；兰州市卫生健康科技发展项目(2021004)；甘肃省“双一流”科研重点项目(GSSYLXM-05) |
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| Research Progress on the Mechanism of Non-coding RNA Regulation of Bone Reconstruction in Osteoporosis and the Therapeutic Mechanism of Traditional Chinese Medicine for Tonifying Kidney and Strengthening Bone |
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WANG Xiaxia1, AN Fangyu1,2, YAN Chunlu1,2,3, SUN Bai1, WANG Chunmei1, LIU Ying1, SHI Yao1, YUAN Lingqing1, LYU Donghui1, ZHAO Yanzhen1
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1.Gansu University of Chinese Medicine, Lanzhou 730000, China;2.Key Laboratory of Chronic Diseases for Prevention and Treatment of Traditional Chinese Medicine of Gansu Province, Lanzhou 730000, China;3.Research Center of Traditional Chinese Medicine of Gansu Province, Lanzhou 730000, China
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| Abstract: |
| Non-coding RNAs(ncRNAs) are special RNAs that they don't have protein coding function, but they can affect chromosome structure, gene transcription and participate in the processes of epigenetic modifications. ncRNAs include long non-coding RNAs, microRNA, etc. In recent years, it has been found that these ncRNAs can maintain bone remodeling by adjusting bone resorption and formation in osteoporosis(OP). In the future, it may be a key target of the drug action screening which is clarifying the regulatory mechanism of ncRNAs in the occurrence and development of OP. OP belongs to bone rheumatism category in traditional Chinese medicine, according to the theory of “the kidney generating marrow and dominating bone” in traditional Chinese medicine, kidney tonifying and bone strengthening formulas are used to treat the OP in clinic, and the curative effect is remarkable. It has been found that kidney tonifying and bone strengthening prescriptions can enhance the proliferation of osteoblasts or inhibit the differentiation of osteoclasts by up-regulating or down-regulating the expression of ncRNA, and finally maintain OP bone homeostasis, thus exerting therapeutic effect. However, the specific molecular mechanism is still in its exploratory stage. Therefore, this paper summarized the molecular mechanism of kidney tonifying and bone strengthening prescriptions regulating ncRNAs in the treatment of OP in recent years, in order to provide the new ideas for the screening of the key therapeutic targets of OP drugs and the prevention and treatment of OP with traditional Chinese medicine. |
| Key words: traditional Chinese medicine tonifying kidney and strengthening bone osteoporosis non-coding RNA bone remodeling |
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