| 引用本文: | 柳颖,安方玉,颜春鲁,王霞霞,孙柏,汪春梅,石瑶,袁灵青,吕栋辉,赵延真.骨质疏松症中HIF-1α诱导的骨细胞铁死亡机制研究进展[J].中国现代应用药学,2023,40(11):1556-1562. |
| LIU Ying,AN Fangyu,YAN Chunlu,WANG Xiaxia,SUN Bai,WANG Chunmei,SHI Yao,YUAN Lingqing,LYU Donghui,ZHAO Yanzhen.Research Progress on the mechanism of ferroptosis by HIF-1α induced in osteocyte of osteoporosis[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(11):1556-1562. |
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| 骨质疏松症中HIF-1α诱导的骨细胞铁死亡机制研究进展 |
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柳颖1, 安方玉1,2, 颜春鲁1,2,3, 王霞霞1, 孙柏1, 汪春梅1, 石瑶1, 袁灵青1, 吕栋辉1, 赵延真1
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1.甘肃中医药大学, 兰州 730000;2.甘肃省高校重大疾病分子医学与中医药防治研究重点实验室, 兰州 730000;3.甘肃省中医药研究中心, 兰州 730000
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| 摘要: |
| 缺氧诱导因子-1α(hypoxia inducible factor-1α，HIF-1α)作为缺氧反应的主要调节因子，可通过调控成骨-血管耦合、雌激素分泌、糖酵解等过程来调节机体成骨细胞-破骨细胞代谢之间的平衡，在骨质疏松症的发生发展中发挥重要作用。有研究表明，HIF-1α与铁死亡密切相关。铁死亡作为一种铁依赖性脂质过氧化驱动下诱发细胞死亡的特殊形式，与肿瘤及退行性疾病的发生发展也密切相关。近年来的研究也发现，HIF-1α诱导的骨细胞铁死亡也参与骨质疏松症的发生。基于此，本文综述近年来有关HIF-1α对成骨细胞、破骨细胞、骨髓间充质干细胞及铁死亡分子调控机制，为临床诊疗提供更多的参考。 |
| 关键词: 骨质疏松症 缺氧诱导因子-1α 铁死亡 成骨细胞 破骨细胞 |
| DOI：10.13748/j.cnki.issn1007-7693.20221197 |
| 分类号:R683 |
| 基金项目:国家自然科学基金项目(82060872)；甘肃省自然科学基金项目(21JR11RA138)；兰州市卫生健康科技发展项目(2021004)；兰州市科技计划项目(2022-3-22)；甘肃省高等学校青年博士基金项目(2022QB-091) |
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| Research Progress on the mechanism of ferroptosis by HIF-1α induced in osteocyte of osteoporosis |
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LIU Ying1, AN Fangyu1,2, YAN Chunlu1,2,3, WANG Xiaxia1, SUN Bai1, WANG Chunmei1, SHI Yao1, YUAN Lingqing1, LYU Donghui1, ZHAO Yanzhen1
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1.Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China;2.Key Laboratory of Molecular Medicine and Chinese Medicine Prevention and Treatment of Major Diseases in Gansu Universities, Lanzhou 730000, China;3.Gansu Provincial Research Center of Traditional Chinese Medicine, Lanzhou 730000, China
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| Abstract: |
| Hypoxia-inducible factor-1α(HIF-1α), as the main regulator of hypoxia response, may play an important role in osteoporosis development, which can regulate the balance between osteoblast-osteoclast metabolism by regulating osteoblast- vascular coupling, estrogen secretion, glycolysis and other processes. It has been shown that HIF-1α is strongly linked with ferroptosis. As a special form of cell death induced by iron-dependent lipid peroxidation, ferroptosis has been implicated in many diseases, such as carcinogenesis, degenerative disease. Recent studies indicated that HIF-1α induced to ferroptosis of bone cell, which is involved in osteoporosis genesis and development. Based on this, this review focused on advances in the molecular regulation mechanism of osteoblasts, osteoclasts, bone marrow mesenchymal stem cells and ferroptosis by HIF-1α, in order to provide more references for clinical diagnosis and treatment. |
| Key words: osteoporosis hypoxia inducible factor-1α ferroptosis osteoblast osteoclast |
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