基于皮肤微生态的炎症性皮肤病和衰老治疗策略

陈洁; 黄永焯; 沈岚<sup>*</sup>; 王冰<sup>*</sup>

引用本文:	陈洁,黄永焯,沈岚,王冰.基于皮肤微生态的炎症性皮肤病和衰老治疗策略[J].中国现代应用药学,2022,39(8):1110-1120.
	CHEN Jie,HUANG Yongzhuo,SHEN Lan,WANG Bing.Skin Microenvironment-based Treatment Strategies for Inflammatory Skin Diseases and Aging[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(8):1110-1120.

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基于皮肤微生态的炎症性皮肤病和衰老治疗策略
陈洁^1,2, 黄永焯², 沈岚¹, 王冰²
1.上海中医药大学中药学院, 上海 201203;2.中国科学院上海药物研究所药物制剂研究中心, 上海 201203

摘要:

皮肤微生态在调控微生物和内稳态方面发挥着关键作用，与炎症性皮肤病及皮肤衰老存在密切联系。本文总结了皮肤微生态的组成与作用、皮肤疾病与微生态之间的关系、炎症性皮肤病和皮肤衰老的微生态调节治疗策略，为皮肤疾病的临床治疗及药物开发提供参考。

关键词: 皮肤微生态炎症皮肤衰老治疗

DOI：10.13748/j.cnki.issn1007-7693.2022.08.017

分类号:R986

基金项目:上海市自然科学基金项目(21ZR1475200)

Skin Microenvironment-based Treatment Strategies for Inflammatory Skin Diseases and Aging

CHEN Jie^1,2, HUANG Yongzhuo², SHEN Lan¹, WANG Bing²

1.School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2.Center for Pharmaceutics Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, China

Abstract:

The skin microenvironment plays a key role in regulating skin microbiome and homeostasis, and is closely related to inflammatory skin diseases and skin aging. This review summarized the composition and function of the skin microenvironment, the relationship between skin diseases and microenvironment, and the treatment strategies of microenvironment regulation for inflammatory skin diseases and skin aging to provide references for the clinical treatment and drug development of skin diseases.

Key words: skin microenvironment inflammations skin aging strategy