| 引用本文: | 李莉,顾相帅,乔芳霞,牛阳,马英锋,张金玉,杨建宏.中药骨伤凝胶贴剂的经皮渗透性研究[J].中国现代应用药学,2022,39(8):1048-1053. |
| LI Li,GU Xiangshuai,QIAO Fangxia,NIU Yang,MA Yingfeng,ZHANG Jinyu,YANG Jianhong.Research on the Transdermal Permeability of the Traditional Chinese Medicine Gushang Gel Patch[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(8):1048-1053. |
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| 中药骨伤凝胶贴剂的经皮渗透性研究 |
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李莉1, 顾相帅1, 乔芳霞1, 牛阳2, 马英锋2, 张金玉3, 杨建宏1
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1.宁夏医科大学, 药学院, 银川 750001;2.宁夏医科大学, 宁夏少数民族医药现代化教育部重点实验室, 银川 750001;3.吴忠马莲渠张氏医院, 宁夏 吴忠 750021
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| 摘要: |
| 目的 探讨药粉目数及透皮吸收促进剂对中药骨伤凝胶贴剂经皮渗透作用的影响。方法 以羟基红花黄色素A和血竭素为评价指标，采用桨碟法评价凝胶贴剂的体外释放行为，采用Franz扩散池法考察药粉目数及透皮吸收促进剂对凝胶贴剂透皮吸收的影响。结果 与氮酮和薄荷脑相比，肉豆蔻酸异丙酯对于羟基红花黄色素A和血竭素的促渗作用最好，其最佳用量为3%，200目的药粉相对于80目在体外释放及有效成分的经皮吸收方面没有明显影响。结论 药粉目数对凝胶贴剂经皮渗透作用的影响不显著，肉豆蔻酸异丙酯透皮吸收促进剂能显著提高凝胶贴剂的透皮吸收。 |
| 关键词: 凝胶贴剂 体外释放 经皮渗透 透皮吸收促进剂 药粉目数 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.08.007 |
| 分类号:R285.5 |
| 基金项目:宁夏回族自治区重点研发计划项目(2017BY084)；宁夏医科大学特殊人才科研启动项目(XT2015010) |
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| Research on the Transdermal Permeability of the Traditional Chinese Medicine Gushang Gel Patch |
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LI Li1, GU Xiangshuai1, QIAO Fangxia1, NIU Yang2, MA Yingfeng2, ZHANG Jinyu3, YANG Jianhong1
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1.Ningxia Medical University, School of Pharmacy, Ministry of Education, Yinchuan 750001, China;2.Ningxia Medical University, Key Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education, Yinchuan 750001, China;3.Wuzhong Malianqu Zhang's Hospital, Wuzhong 750021, China
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| Abstract: |
| OBJECTIVE To investigate the influence of the powder mesh and the percutaneous absorption enhancer on the percutaneous penetration of the traditional Chinese medicine Gushang gel patch. METHODS Using hydroxysafflor yellow A and dracorhodin as evaluation indicators, the paddle method was used to evaluate the in vitro release behavior of the gel patch, and the Franz diffusion cell method was used to investigate the effect of powder mesh and transdermal absorption enhancers on the transdermal absorption of gel patch. RESULTS Compared with azone and menthol, isopropyl myristate had the best penetration promoting effect on hydroxysafflor yellow A and dracorhodin. The optimal dosage was 3%, 200 mesh powder had no significant effect on the in vitro release and transdermal absorption of active components compared with 80 mesh powder. CONCLUSION The powder mesh has no significant effect on the transdermal penetration of the gel patch whereas the transdermal absorption enhancer of isopropylmyristate can improve the transdermal absorption of the gel patch obviously. |
| Key words: gel patch in vitro release transdermal penetration transdermal absorption enhancer powder mesh |
