| 引用本文: | 朱荣玥,蔡梦如,姚宇,尹东阁,王开心,胡雪凌,付婷婷,黄华婷,廖诗朗,尹兴斌,倪健.PEG化的金属有机骨架材料递药系统研究进展[J].中国现代应用药学,2022,39(20):2684-2690. |
| ZHU Rongyue,CAI Mengru,YAO Yu,YIN Dongge,WANG Kaixin,HU Xueling,FU Tingting,HUANG Huating,LIAO Shilang,YIN Xingbin,NI Jian.Advance of PEGylated Metal-orgaric Framworks Drug Delivery Systems[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(20):2684-2690. |
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| PEG化的金属有机骨架材料递药系统研究进展 |
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朱荣玥, 蔡梦如, 姚宇, 尹东阁, 王开心, 胡雪凌, 付婷婷, 黄华婷, 廖诗朗, 尹兴斌, 倪健
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北京中医药大学中药学院, 北京 102488
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| 摘要: |
| 金属有机骨架材料(metal-organic frameworks，MOFs)因其功能多样化、比表面积大、孔径可控、孔隙率高等优势，在临床诊断和药物递送中受到了广泛关注。但MOFs还存在着诸多不足，比如水溶性低、分散性差、血液循环时间短、有突释效应等。为了改善以上不足，常用聚乙二醇(polyethylene glycol，PEG)对MOFs进行表面修饰，使其理化性能有不同程度的改善。本文对PEG化MOFs递药系统研究进展进行了综述，包括MOFs PEG化的方法、PEG在MOFs表面的存在形式和PEG化MOFs递药系统在中药、化学药中的实际应用等，分析PEG修饰在基于MOFs的中药、化学药递送系统研究中所起到的作用与不足，以期为PEG化MOFs递药系统的相关研究提供一些参考。 |
| 关键词: 金属有机骨架材料 PEG 递药系统 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.20.017 |
| 分类号:R94 |
| 基金项目:北京市自然科学基金资助项目(7202121)；北京市优秀人才培养计划基金资助项目(2017000020124G295)；中央高校基本科研业务费专项资金资助项目(2020-JYB-ZDGG-046) |
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| Advance of PEGylated Metal-orgaric Framworks Drug Delivery Systems |
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ZHU Rongyue, CAI Mengru, YAO Yu, YIN Dongge, WANG Kaixin, HU Xueling, FU Tingting, HUANG Huating, LIAO Shilang, YIN Xingbin, NI Jian
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School of Chinese Material Medica, Beijing University of Chinese Medicine, Beijing 102488, China
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| Abstract: |
| Metal-organic frameworks(MOFs) have received extensive attention in clinical diagnosis and drug delivery due to their diversified functions, large specific surface area, controllable pore size, and high porosity. However, MOFs still have many shortcomings, such as low water solubility, poor dispersion, short blood circulation time, and burst release effect. In order to improve the above shortcomings, polyethylene glycol(PEG) is commonly used to modify the surface of MOFs to improve their physical and chemical properties to varying degrees. This article reviewed the research advances of the PEGylated MOFs drug delivery system, including the methods of PEGylation of MOFs, the existing forms of PEG on the surface of MOFs, and the practical application of the PEGylated MOFs drug delivery system in the domain of traditional Chinese medicine and chemical medicine. This article analyzed the role and deficiencies of PEG modification in the research of MOFs-based drug delivery systems used in traditional Chinese medicine and chemical medicine, in order to provide some references for related researches on PEGylated MOFs drug delivery systems. |
| Key words: metal-organic frameworks polyethylene glycol drug delivery systems |
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