| 引用本文: | 王飞强,张子琪,冯庆媛,白杨,刘悠云,岳芸芸,尚靖.皮肤毒理学检验中的替代方法和整合测试评估方法[J].中国现代应用药学,2021,38(24):3091-3096. |
| WANG Feiqiang,ZHANG Ziqi,FENG Qingyuan,BAI Yang,LIU Youyun,YUE Yunyun,SHANG Jing.Alternative Methods and Integrated Approaches to Testing and Assessment of Testing Skin Toxicology[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(24):3091-3096. |
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| 摘要: |
| 近些年，随着实验动物“3R”原则的兴起，动物替代实验的研究越来越重要。为了使国产化妆品的开发和国际标准接轨，中国加快了替代实验方法在化妆品“安全性”检验中的应用。针对化妆品对皮肤可能造成的刺激性、致敏性和光毒性等不良反应，本文分别对化妆品皮肤毒理学检验中的替代实验方法及毒理学终点相应的整合测试评估方法（IATA）进行概述。同时，本文也为三维重组皮肤模型和模式生物斑马鱼在化妆品皮肤毒性检验中的应用提供重要依据。 |
| 关键词: 刺激性替代实验 致敏性替代实验 光毒性替代实验 整合测试评估方法 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.24.007 |
| 分类号:R99 |
| 基金项目: |
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| Alternative Methods and Integrated Approaches to Testing and Assessment of Testing Skin Toxicology |
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WANG Feiqiang, ZHANG Ziqi, FENG Qingyuan, BAI Yang, LIU Youyun, YUE Yunyun, SHANG Jing
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Traditional Chinese Medicine College, China Pharmaceutical University, NMPA Key Laboratory for Research and Evaluation of Cosmetics, Nanjing 210098, China
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| Abstract: |
| In recent years, with the rise of the 3R principle of experimental animals, the research of animal replacement experiments has become more and more significant. In order to keep the development of domestic cosmetics in line with international standards, China has accelerated the application of alternative experimental methods in the safety testing of cosmetics. In view of the possible irritation, sensitization, phototoxicity and other adverse reactions of cosmetics to the skin, this paper summarizes the alternative methods and integrated approaches to testing and assessment(IATA) for the toxicological end point of cosmetic skin toxicology. At the same time, this paper also provides an important basis for the application of three-dimensional reconstituted skin model and model biological zebrafish in dermal toxicity test of cosmetics. |
| Key words: alternative experimental methods of irritation alternative experimental methods of allergy alternative experimental methods of phototoxicity integrated approaches to testing and assessment |
