肠道微生物参与偏头痛发病机制的研究进展

常露露; 刘顶鼎<sup>*</sup>; 曾贵荣; 王静茹; 隋怡

引用本文:	常露露,刘顶鼎,曾贵荣,王静茹,隋怡.肠道微生物参与偏头痛发病机制的研究进展[J].中国现代应用药学,2022,39(4):560-565.
	CHANG Lulu,LIU Dingding,ZENG Guirong,WANG Jingru,SUI Yi.Research Progress of Intestinal Microbes Involved in the Pathogenesis of Migraine[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(4):560-565.

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肠道微生物参与偏头痛发病机制的研究进展
常露露¹, 刘顶鼎¹, 曾贵荣², 王静茹¹, 隋怡¹
1.贵州中医药大学, 贵阳 550025;2.湖南省药物安全评价研究中心/新药药效与安全性评价湖南省重点实验室, 长沙 410331

摘要:

偏头痛是临床上常见的一种神经紊乱性疾病,由于其病因复杂,发病机制尚未完全阐明,目前对于偏头痛的防治还处于不断探索阶段。近期研究提出的"微生物群-肠-脑轴"理论为偏头痛发病机制的研究提供了新的可能,其认为肠道微生物通过"肠-脑"轴参与中枢系统的调控可能会导致神经系统疾病的发生。因此,本文通过综述国内外相关文献报道,结合偏头痛的病因及发病机制,详述肠道微生物与神经系统疾病之间的关系,阐明肠道微生物参与偏头痛发生发展的可能机制,并对后续研究进行展望,以期为偏头痛发病机制研究及治疗新药物开发奠定理论基础。

关键词: 肠道微生物神经系统疾病偏头痛 “肠-脑”轴发病机制

DOI：10.13748/j.cnki.issn1007-7693.2022.04.022

分类号:R961

基金项目:国家自然科学基金项目(81860844， 82160894)；贵州省科技计划项目(黔科合基础[2019]1038 号)；贵州中医药大学药效物质基础及作用机理研究中心(贵中医党办发〔 2019〕 70 号)；贵州中医药大学研究生教育创新计划项目(YCXZR2020001)

Research Progress of Intestinal Microbes Involved in the Pathogenesis of Migraine

CHANG Lulu¹, LIU Dingding¹, ZENG Guirong², WANG Jingru¹, SUI Yi¹

1.Guizhou University of Traditional Chinese Medicine, Guiyang 550025, China;2.Hunan Provincial Research Center for Safety Evaluation of Drugs/Hunan Key Laboratory of Pharmacodynamics and Safety Evaluation of New Drugs, Changsha 410331, China

Abstract:

Migraine is a common neurovascular disease in clinical practice. Due to its complicated etiology, the pathogenesis has not been fully elucidated. At present, the prevention and treatment of migraine is still in the stage of continuous exploration. The "microbiota-gut-brain axis" theory proposed in recent studies provides new possibilities for the mechanism of migraine. It believes that gut microbes participate in the regulation of the central system through the "gut-brain" axis and may lead to neurological diseases. Therefore, this article reviews related articles at home and abroad, combined with the etiology and pathogenesis of migraine, details the relationship between intestinal microbes and neuropathic diseases, clarifies the mechanism of intestinal microbes involved in migraine, and conducts follow-up research. Looking forward, it is expected to lay a theoretical foundation for the research on the pathogenesis of migraine and the development of new therapeutic drugs.

Key words: intestinal microbes neuropathic diseases migraine “gut-brain” axis pathogenesis