| 引用本文: | 蒋国凤,颜春鲁,安方玉,刘永琦,石瑶,吕栋辉,赵延真,李孟瀚,李朝晖,孟祥睿.miRNA介导的TLR4炎症信号通路在辐射损伤中的研究进展[J].中国现代应用药学,2022,39(11):1495-1502. |
| JIANG Guofeng,YAN Chunlu,AN Fangyu,LIU Yongqi,SHI Yao,LYU Donghui,ZHAO Yanzhen,LI Menghan,LI Zhaohui,MENG Xiangrui.Advances in miRNA-mediated TLR4 Inflammatory Signaling Pathway in Radiation Injury[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(11):1495-1502. |
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| miRNA介导的TLR4炎症信号通路在辐射损伤中的研究进展 |
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蒋国凤1, 颜春鲁1,2,3, 安方玉1,3, 刘永琦1,2,3, 石瑶1, 吕栋辉1, 赵延真1, 李孟瀚1, 李朝晖1, 孟祥睿1
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1.甘肃中医药大学, 兰州 730000;2.甘肃省中医药研究中心, 兰州 730000;3.甘肃省中医药防治慢性疾病重点实验室, 兰州 730000
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| 摘要: |
| 放疗是目前全球公认的治疗各种肿瘤的主要手段之一，但放疗过程中产生的各类射线会对辐射周围的正常组织造成炎症性损害，因此探寻有效治疗靶点以改善辐射造成的炎症性损伤，提高放疗疗效是当务之急。研究发现，微小RNA （microRNA，miRNA）作为一种新型的炎症调节因子，主要通过TLR4介导的NF-κB信号通路来调控辐射诱发的炎症反应。因此，miRNA与TLR4形成的交互网络系统有望成为防辐射损伤药物研发的筛选靶点。本文从TLR4介导的炎症相关信号通路对辐射的调控作用、miRNA对辐射的调控作用、miRNA对辐射中TLR4/NF-κB信号通路调控的炎症反应的靶向作用及靶向miRNA-TLR4改善辐射后炎症反应的治疗策略4个方面进行综述，以期找到miRNA靶向调控TLR4介导的NF-κB信号通路的有效靶点，为辐射损伤的防治研究提供新的思路。 |
| 关键词: miRNA TLR4信号通路 辐射损伤 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.11.016 |
| 分类号:R965.2 |
| 基金项目:国家自然科学基金项目（81760797）；甘肃省“双一流”科研重点项目（GSSYLXM-05）；甘肃省优秀研究生“创新之星”项目（2021CXZX-746）；甘肃中医药大学科学研究与创新基金（2021KCYB-4） |
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| Advances in miRNA-mediated TLR4 Inflammatory Signaling Pathway in Radiation Injury |
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JIANG Guofeng1, YAN Chunlu1,2,3, AN Fangyu1,3, LIU Yongqi1,2,3, SHI Yao1, LYU Donghui1, ZHAO Yanzhen1, LI Menghan1, LI Zhaohui1, MENG Xiangrui1
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1.Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China;2.Research Center of Traditional Chinese Medicine, Lanzhou 730000, China;3.Key Laboratory of Chronic Diseases for Prevention and Treatment of Traditional Chinese Medicine, Lanzhou 730000, China
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| Abstract: |
| Radiotherapy is currently recognized as one of the major treatments for various tumors worldwide, but the various types of radiation produced during radiotherapy can cause inflammatory damage to the normal tissues surrounding the radiation. Therefore, it is imperative to explore effective therapeutic targets to improve the inflammatory damage caused by radiation and enhance the efficacy of radiotherapy. It has been found that microRNA(miRNA), a novel inflammatory regulator, regulates radiation-induced inflammatory responses mainly through the TLR4-mediated NF-κB signaling pathway. Therefore, the interactive network system formed by miRNAs and TLR4 is expected to be a screening target for the development of drugs against radiation damage. This review summarizes four aspects, including the regulatory role of TLR4-mediated inflammation-related signaling pathway on radiation, the regulatory role of miRNA on radiation and the targeting role of miRNA on TLR4/NF-κB signaling pathway-regulated inflammatory response in radiation, in order to find effective targets for miRNA-targeted regulation of TLR4-mediated NF-κB signaling pathway and provide new ideas for the prevention and treatment of radiation injury. |
| Key words: miRNA TLR4 signaling pathway radiation injury |
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