| 引用本文: | 陈希西,孙雨颉,杨延泽,黄宇虹,吕春晓.微粒体环氧水解酶与相关疾病的研究进展[J].中国现代应用药学,2021,38(23):3037-3044. |
| CHEN Xixi,SUN Yujie,YANG Yanze,HUANG Yuhong,LYU Chunxiao.Research Progress of Microsomal Epoxy Hydrolase and Related Diseases[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(23):3037-3044. |
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| 摘要: |
| 微粒体环氧水解酶（microsomal epoxide hydrolase，EPHX1）是一种进化高度保守的生物转化酶，基因编码提示其具有遗传多态性，因此EPHX1基因有多种单核苷酸多态性（single nucleotide polymorphism，SNP），其中有2种常见SNP（rs1051740与rs2234922）可以导致酶活性发生变化。EPHX1在功能上还具有广泛的底物选择性，可生物活化胆固醇等多种底物，并参与异源物质的代谢以达到解毒的作用，还可通过催化作用激活多环芳烃的致癌性而诱发癌变。因此，EPHX1基因结构、分布、多态性、生理功能与人类多种疾病息息相关。本文将对EPHX1基因及与之相关疾病的关键点总结归纳，为EPHX1基因进一步研究提供参考。 |
| 关键词: 微粒体环氧水解酶 基因 SNP 生理功能 疾病 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.23.021 |
| 分类号:R966 |
| 基金项目:国家自然科学基金项目（81803930） |
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| Research Progress of Microsomal Epoxy Hydrolase and Related Diseases |
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CHEN Xixi1,2, SUN Yujie2, YANG Yanze2, HUANG Yuhong1, LYU Chunxiao1
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1.Department of Clinical Pharmacology, The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China;2.Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
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| Abstract: |
| Microsomal epoxy hydrolase(EPHX1) is an evolutionary highly conserved bioconvertase. The genetic code suggests that it has genetic polymorphism. Therefore, the EPHX1 gene has a variety of single nucleotide polymorphism(SNP), which there are two common SNP(rs1051740 and rs2234922) and lead to changes in enzyme activity. EPHX1 also has a wide range of substrate selectivity in function. It can biologically activate a variety of substrates, such as cholesterol, and participate in the metabolism of heterologous substances to achieve detoxification. It can also activate the carcinogenicity of polycyclic aromatic hydrocarbons through catalysisto induce cancer. Therefore, EPHX1 gene structure, distribution, polymorphism, and physiological function are related to multiple human diseases. This article will summarize the key points of EPHX1 gene and related diseases, then provide reference for further research of EPHX1 gene. |
| Key words: microsomal epoxyhydrolase gene SNP physiological function disease |
