| 引用本文: | 立新,苏力德,奥·乌力吉,那仁满都拉.再生障碍性贫血致病分子机制研究进展[J].中国现代应用药学,2021,38(17):2150-2155. |
| LI Xin,SU Lide,WU Liji·AO,NARANMANDURA Hua.Research Progress on the Molecular Biological Mechanism of Aplastic Anemia[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(17):2150-2155. |
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| 再生障碍性贫血致病分子机制研究进展 |
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立新1,2, 苏力德3, 奥·乌力吉1, 那仁满都拉4
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1.内蒙古民族大学, 内蒙古 通辽 028000;2.内蒙古民族大学附属医院, 内蒙古 通辽 028000;3.内蒙古国际蒙医医院, 呼和浩特 010000;4.浙江大学医学院公共卫生学院, 杭州 310000
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| 摘要: |
| 再生障碍性贫血（aplastic anemia，AA）是一类由多种致病因素共同作用导致的骨髓造血功能衰竭综合征。由于致病因素多、作用机制复杂，目前对AA的发病机制尚未形成一致的观点。本文结合了近年来国内外报道AA致病机制的研究进展，从造血干/祖细胞缺乏、骨髓微环境异常、免疫功能障碍、遗传因素等方面，全面综述了AA发病的最新分子生物学机制，以期为临床预防、诊断及治疗AA提供新思路。 |
| 关键词: 再生障碍性贫血 造血干细胞 骨髓微环境 免疫异常 遗传因素 研究进展 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.17.017 |
| 分类号:R966 |
| 基金项目:国家自然科学基金项目（81673521，81872942） |
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| Research Progress on the Molecular Biological Mechanism of Aplastic Anemia |
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LI Xin1,2, SU Lide3, WU Liji·AO1, NARANMANDURA Hua4
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1.Inner Mongolia University For Nationalities, Tongliao 028000, China;2.Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao 028000, China;3.Inner Mongolia International Mongolia Hospital, Hohhot 010000, China;4.School of Medicine and Public Health, Zhejiang University, Hangzhou 310000, China
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| Abstract: |
| Aplastic anaemia(AA) is a bone marrow hematopoietic failure syndrome that developed from various pathogenic factors. Due to many pathogenic factors and complex mechanism of action, there is no consensus on the pathogenesis of AA. This article combines the research progress reported at home and abroad in recent years on the pathogenesis of AA, and comprehensively reviews the latest molecular biological mechanisms of the pathogenesis of AA in terms of lack of hematopoietic stem/progenitor cells, abnormal bone marrow microenvironment, immune dysfunction, and genetic factors. It hopes to provide new ideas for clinical prevention, diagnosis and treatment of AA. |
| Key words: aplastic anaemia hemopoietic stem cell bone marrow microenvironment immune dysfunction inheritance factors research progress |
