| 引用本文: | 李萌,孟昭珂,丁仲杰.复方氨酚葡锌分散片处方及其制备工艺研究[J].中国现代应用药学,2010,27(3):235-239. |
| .Investigation on the Formula of Compound Paracetamol and Zinc Gluconate Dispersed Tablets[J].Chin J Mod Appl Pharm(中国现代应用药学),2010,27(3):235-239. |
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| 摘要: |
| 目的 研究复方氨酚葡锌分散片的制备工艺和最佳处方。方法 以崩解时间为考察指标，采用单因素试验和正交设计试验，对复方氨酚葡锌分散片的处方进行优化。结果 按优化处方工艺制备的复方氨酚葡锌分散片，符合分散片的质量要求，并且其溶出较普通片快。结论 本法研制的复方氨酚葡锌分散片处方合理、工艺可行，适合工业化生产。 |
| 关键词: 复方氨酚葡锌分散片 崩解时间 正交设计 溶出度 |
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| Investigation on the Formula of Compound Paracetamol and Zinc Gluconate Dispersed Tablets |
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LI Meng MENG Zhaoke DING Zhongjie
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| Abstract: |
| OBJECTIVE To investigate the preparation technique and the optimal formulation of compound paracetamol and zinc gluconate dispersed tablets. METHODS The formula of compound paracetamol and zinc gluconate dispersed tablets were optimized in terms of disintegration time by studying single factor and orthogonal design tests. RESULTS The products formulated with the optimum techniques met the quality specification of dispersed tablets. And they obviously dissolved faster than the common tablets. CONCLUSION This prescription and technology of compound paracetamol and zinc gluconate dispersed tablets are reasonable, effective and suitable for industrial production. |
| Key words: compound paracetamol and zinc gluconate dispersed tablets disintegration time orthogonal design dissolubility |
