| 引用本文: | 陈国广，陈锋，陆高圣，李学明，韦萍.响应面分析法优化利培酮微球体外加速释放条件[J].中国现代应用药学,2009,(2):134-139. |
| CHEN Guoguang, CHEN Feng,LU Gaosheng,LI Xueming, WEI Ping.Studies on the Optimizing Condition of Risperdione Microsphere in Vitro Release by RSM[J].Chin J Mod Appl Pharm(中国现代应用药学),2009,(2):134-139. |
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| 摘要: |
| 目的建立微球体外释放快速分析方法，考察其与体内相关性。方法制备生物可降解的利培酮微球，利用Box-Benhnken中心组合实验和响应面分析法，优化利培酮微球体外加速实验条件。结果体外加速释放最佳条件：温度48.4 ℃，磷酸盐缓冲液的pH 4.62，有机溶剂浓度为24%。验证实验表明优选工艺参数较为理想。结论优选的体外加速释放与长期释放及体内相关性良好。 |
| 关键词: 响应面分析法 利培酮 微球 加速释放 |
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| Studies on the Optimizing Condition of Risperdione Microsphere in Vitro Release by RSM |
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CHEN Guoguang, CHEN Feng,LU Gaosheng,LI Xueming, WEI Ping
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| Abstract: |
| OBJECTIVE To optimize the conditions of the microsphere release in vitro rapidlly.METHODS To prepare biodegradable risperdione microsphere, the method of Box-Benhnke design and the Response Surface Analysis were used to optimize the experiment conditions of risperdione microsphere accelerating release in vitro.RESULTS The conditions of accelerating release in vitro were optimized: temperature 48 ℃，phosphate buffered saline pH 4.62，concentration of solvent is 24%.The experiment indicated that the optimum parameters were satisfactory.CONCLUSION The optimized accelerating release in vitro and long-term release were well correlated. |
| Key words: response surface analysis risperidone microspheres accelerating release |
