大剂量甲氨蝶呤在急性淋巴细胞白血病患儿体内的药动学研究

张善堂a;屈建a;杨林海b;唐丽琴a;王宁玲b

引用本文:	张善堂a;屈建a;杨林海b;唐丽琴a;王宁玲b.大剂量甲氨蝶呤在急性淋巴细胞白血病患儿体内的药动学研究[J].中国现代应用药学,2008,(5):454-458.
	ZHANG Shan-tang a,QU Jian a,YANG Lin-hai b,TANG Li-qin a,WANG Ning-ling b.Pharmacokinetics of High-Dose Methotrexate Infusion in Children with Acute Lymphoblastic Leukemia[J].Chin J Mod Appl Pharm(中国现代应用药学),2008,(5):454-458.

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大剂量甲氨蝶呤在急性淋巴细胞白血病患儿体内的药动学研究
张善堂a;屈建a;杨林海b;唐丽琴a;王宁玲b

作者	单位
张善堂a;屈建a;杨林海b;唐丽琴a;王宁玲b

摘要:

关键词: 甲氨蝶呤急性淋巴细胞白血病儿童药动学高效液相色谱法

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Pharmacokinetics of High-Dose Methotrexate Infusion in Children with Acute Lymphoblastic Leukemia

ZHANG Shan-tang a,QU Jian a,YANG Lin-hai b,TANG Li-qin a,WANG Ning-ling b

Abstract:

OBJECTIVE To evaluate the pharmacokinetics of methotrexate(MTX)in children with acute lymphoblastic leukemia(ALL)treated with high-dosage infusion of MTX and combination with calcium folinate(CF)rescued.METHODS The serum samples were collected at differen

Key words: methotrexate acute lymphoblastic leukemia(ALL) children pharmacokinetics HPLC