| 引用本文: | 邹霈;刘娅灵;谢敏浩;何拥军;吴军;王洪勇;罗世能.离子型X线造影剂碘羟拉酸的合成[J].中国现代应用药学,2007,(6):475-476. |
| ZOU Pei,LIU Ya-ling,XIE Min-hao,HE Yong-jun,Wu Jun,Wang Hong-yong,LUO Shi-neng.Synthesis of Ioxitalamic Acid as Ionic X-ray Contrast Agent[J].Chin J Mod Appl Pharm(中国现代应用药学),2007,(6):475-476. |
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| 摘要: |
| 目的离子型X线造影剂碘羟拉酸的合成。方法以5-硝基异酞酸为原料,经酯化、酰胺化、还原、碘化和乙酰化反应等步骤制得碘羟拉酸。结果合成产物经元素分析、核磁共振谱和质谱确证了化学结构。结论该工艺路线方法简便,原料易得,适合工业化生产。 |
| 关键词: 非离子型X线造影剂 碘羟拉酸 化学合成 |
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| Synthesis of Ioxitalamic Acid as Ionic X-ray Contrast Agent |
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ZOU Pei,LIU Ya-ling,XIE Min-hao,HE Yong-jun,Wu Jun,Wang Hong-yong,LUO Shi-neng
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| Abstract: |
| OBJECTIVE To synthesize Ioxitalamic acid,a ionic x-ray contrast agent.METHODS Ioxitalamic acid was synthesized by steps of esterification,amidation,reduction,iodization and acetylation from 5-nitro-isophthalic acid.RESULTS The chemical structure of the sy |
| Key words: non-ionic x-ray contrast agent Ioxitalamic acid chemical synthesis |
