异烟肼与利福平合用致肝毒性增加机制的研究概况

薛洪源;侯艳宁;刘会臣

引用本文:	薛洪源;侯艳宁;刘会臣.异烟肼与利福平合用致肝毒性增加机制的研究概况[J].中国现代应用药学,2002,(6):463-465.
	Xue Hongyuan, Hou Yanning, Liu Huichen.The general investigation of the increased hepatotoxicity caused by isoniazid in combination with rifampin[J].Chin J Mod Appl Pharm(中国现代应用药学),2002,(6):463-465.

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异烟肼与利福平合用致肝毒性增加机制的研究概况
薛洪源;侯艳宁;刘会臣

作者	单位
薛洪源;侯艳宁;刘会臣

摘要:

关键词: 异烟肼利福平联合用药肝毒性细胞色素P450酶肝药酶

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The general investigation of the increased hepatotoxicity caused by isoniazid in combination with rifampin

Xue Hongyuan, Hou Yanning, Liu Huichen

Abstract:

OBJECTIVE:To summarize the investigations of the increased hepatotoxicity caused by the combined action of isoniazid (INH) and rifampicin (RFP) . METHOD:To consult recent years' papers, summarize the mechanisms of the metabolism of INH, and analyse the i

Key words: isoniazid, rifampicin, drug interactions, hepatic enzymes , microsomal cytochrome P450, hepatotoxicity