| 摘要: |
| 目的 综述国内外抗MRSA(耐甲氧西林金黄色葡萄球菌)天然产物的研究进展。方法 查阅关于抗MRSA天然产物的国内外文献。结果 共计报道抗MRSA天然产物约85个，其中58个来源于微生物，26个来源于植物，另外1个来源于海洋动物海绵；主要包括环肽类、生物碱类、萜类、醌类、黄酮类和大环内酯类等结构类型，其中11个化合物含有氯、溴或硫元素；30个化合物体外抗MRSA的MIC＜5 μg·mL-1。结论 微生物和植物的次级代谢产物中含有结构特异、活性显著的抗MRSA成分，随着临床上耐药病原菌不断地被分离发现和防治MRSA感染形势的日趋严峻，有必要对微生物和植物的抗MRSA成分展开广泛而又深入的研究。 |
| 关键词: 抗MRSA 天然产物 成分 次级代谢产物 |
| DOI： |
| 分类号: |
| 基金项目:江西农业大学博士启动基金(09003267) |
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| Progress in Natural Products with Anti-MRSA Activity |
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YUAN Ganjun1, LI Peibo2
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1.College of Bioscience and Bioengineering, Jiangxi Agricultral University, Nanchang 330045, China;2.College of Life Science, Sun Yat-sen University, Guangzhou 510275, China
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| Abstract: |
| OBJECTIVE To review the general situation of progress in natural products with anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. METHODS Consult the literatures at home and abroad. RESULTS Eighty five natural products including cyclic peptides, alkaloids, terpenoids, quinones, flavanones and macrolides were reported. Among them, fifty eight compounds were isolated from the metabolites of microorganisms, twenty six compounds from plants, and one compound from a sponge. There was one element of chlorine, or bromine and sulfur in the structures of eleven compounds. Thirty compounds showed anti-MRSA activities, and their minimum inhibitory concentrations were lower than 5 μg·mL-1. CONCLUSION Based on many compounds with anti-MRSA activity isolated from the metabolites of microorganisms and plants, it is necessary to develop and research widely when the situation infected by drug-resistance pathogenic bacteria including MRSA is daily grimness. |
| Key words: anti-MRSA natural product constituent secondary metabolite |
