| 引用本文: | 张霞,王荣,王文苹,侯延辉,李治芳.复方芸归颗粒制备工艺研究[J].中国现代应用药学,2011,28(3):222-226. |
| ZHANG Xia,WANG Rong,WANG Wenping,HOU Yanhui,LI Zhifang.Optimization of the Preparation Process of Complex Prescription Yungui Granules[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(3):222-226. |
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| 复方芸归颗粒制备工艺研究 |
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张霞1,2,3, 王荣4, 王文苹1,2,3, 侯延辉1,2,3, 李治芳1,2,3
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1.宁夏医科大学, a.药学院，银川 750004;2.宁夏回药现代化工程技术研究中心，银川 750004;3.宁夏医药研究所，银川 750004;4.1.宁夏医科大学, b.中医学院，银川 750004
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| 摘要: |
| 目的 优选复方芸归颗粒最佳制备工艺。方法 以方中主药当归活性成分阿魏酸、枳壳的活性成分柚皮苷提取量为评价指标，高效液相色谱法定量，采用L9(34)正交设计试验法，对复方芸归颗粒制备过程中的水提取工艺进行优化，并进行制粒工艺研究。结果 最佳提取工艺为：加水量10倍、提取时间为1.5 h、提取次数为2次；制粒工艺：提取液减压浓缩后喷雾干燥得药粉，以90%乙醇作润湿剂，药粉∶辅料为1∶0.5，矫味剂用量为0.2%。结论 该工艺合理可行，适用于复方芸归颗粒的制备。 |
| 关键词: 复方芸归颗粒 制备工艺 正交试验 阿魏酸 柚皮苷 高效液相色谱法 |
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| 基金项目:宁夏医科大学特殊人才启动基金(XT200807) |
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| Optimization of the Preparation Process of Complex Prescription Yungui Granules |
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ZHANG Xia1,2,3, WANG Rong4, WANG Wenping1,2,3, HOU Yanhui1,2,3, LI Zhifang1,2,3
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1.Ningxia Medical University, a.College of Pharmacy, Yinchuan 750004, China;2.Ningxia Engineering and Technology Research Center for Modernization of Hui Medicine, Yinchuan 750004, China;3.Ningxia Pharmaceutical Institute, Yinchuan 750004, China;4.1.Ningxia Medical University, b.College of Chinese Medicine, Yinchuan 750004, China
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| Abstract: |
| OBJECTIVE To optimize preparation technology of complex prescription Yungui granules(CPYGG). METHODS Using the content of ferulaic acid in Ligustici Radix and naringin in Aurantii Fructus as the index, HPLC was used to quantitative, extraction time, the amout of water, extracting times, degree on extraction technology were evaluated by L9(34) orthogonal design method. Granulating conditions were studied. RESULTS The superior technology of water extraction were as follows: 10 times as much water, extracted 1.5 h for 2 times. Wetting agent was 90% alcohol, extraction powder∶ adjuvant was 1∶0.5, 0.2% sweeting agent was added. CONCLUSION The preparation procedure is stable and feasible, it can be used for the preparation of CPYGG. |
| Key words: complex prescription Yungui granules preparation process orthogonal experiment ferulaic acid naringin HPLC |
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