| 引用本文: | 宋佳欢,李敏,高金湖,邬敏辰.重组人甲状旁腺激素基因工程研究进展[J].中国现代应用药学,2011,28(2):112-116. |
| SONG Jiahuan,LI Min,GAO Jinhu,WU Minchen.Research Advances in Genetic Engineering of Recombinant Human Parathyroid Hormone[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(2):112-116. |
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| 摘要: |
| 甲状旁腺激素(parathyroid hormone，PTH)是由甲状旁腺主细胞分泌的碱性单链多肽类激素。它主要调节脊椎动物体内钙和磷的代谢。目前，PTH及其类似物已成为治疗骨质疏松症的首选药物。随着PTH基因序列的阐明，通过基因工程手段获得高效、低毒、稳定的重组PTH，已成为研究热点。本文对PTH的结构功能、基因工程研究及临床应用问题进行综述。 |
| 关键词: 甲状旁腺激素 骨质疏松 基因工程 |
| DOI： |
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| 基金项目:江南大学国家大学生创新性实验计划(081029519) |
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| Research Advances in Genetic Engineering of Recombinant Human Parathyroid Hormone |
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SONG Jiahuan, LI Min, GAO Jinhu, WU Minchen
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School of Medicine and Pharmaceutics, Jiangnan University, Wuxi 214122, China
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| Abstract: |
| Parathyroid hormone (PTH) is an alkaline polypeptide hormone which is secreted by the parathyroid gland cell. It mainly regulates metabolism of calcium and phosphorus in vertebrates. Currently, PTH and its analogues have been exploited into first-choice drugs for the treatment of osteoporosis. With the elucidation of PTH gene sequence, it has become a research hotspot to obtain recombinant PTH of high-efficiency, low-toxicity and stability by means of genetic engineering. Here we present an overview of structure function, genetic engineering research and clinical application of PTH. |
| Key words: parathyroid hormone osteoporosis genetic engineering |
