| 引用本文: | 顾丽,张君,苏燕.人催乳素受体拮抗剂G129R-hPRL在乳腺肿瘤治疗中的研究进展[J].中国现代应用药学,2011,28(1):30-34. |
| GU Li,ZHANG Jun,SU Yan.Advances in the Research of Human Prolactin Receptor Antagonists G129R-hPRL in Breast Cancer Therapy[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(1):30-34. |
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| 摘要: |
| 目的 介绍特异性人催乳素(PRL)受体拮抗剂G129R-hPRL在乳腺肿瘤治疗中的研究进展。方法 查阅近年来国内外相关文献进行总结和归纳，对G129R-hPRL的功能、作用机制、优缺点、改进措施以及在乳腺肿瘤治疗中的应用和今后的发展方向进行综述。结果 G129R-hPRL通过竞争性拮抗内源性PRL的作用进而抑制乳腺癌细胞增殖，介导癌细胞凋亡，从而发挥其抗肿瘤效应。以G129R-hPRL为基础的多功能融合蛋白、以及与其他抗肿瘤成分联合应用显示出更强的肿瘤抑制效力。结论 G129R-hPRL有望成为一种治疗以及预防乳腺癌的理想药物。 |
| 关键词: 催乳素 催乳素受体拮抗剂 G129R-hPRL 乳腺肿瘤 |
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| 基金项目:内蒙古自治区自然科学基金项目(200711020913) |
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| Advances in the Research of Human Prolactin Receptor Antagonists G129R-hPRL in Breast Cancer Therapy |
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GU Li1, ZHANG Jun2, SU Yan2
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1.Baotou Medical College, Inner Mongolia University of Science and Technology, a.Department of Pathogenic Organism, Baotou 014060, China;2.Department of Biochemistry Andmolecular Biology, Baotou 014060, China
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| Abstract: |
| OBJECTIVE To introduce the progress of specific human prolactin receptor antagonist G129R-hPRL in breast cancer therapy research. METHODS Review the function, mechanism, advantages and disadvantages, improvements, the application and the prospect of the prolactin receptor antagonist G129R-hPRL in therapy of breast tumor through searching and summarizing relevant literatures. RESULTS G129R-hPRL can inhibit proliferation, mediate apoptosis of breast cancer cell and play the role of anti-breast cancer by competitively antagonize endogenous prolactin. G129R-hPRL-based multi-functional fusion protein, as well as combination G129R-hPRL with other anti-tumor component also shows a stronger tumor suppressor effect. CONCLUSION G129R-hPRL is expected to be an ideal drug in treatment and prevention of breast cancer. |
| Key words: prolactin prolactin receptor antagonist G129R-hPRL breast tumor |
