Abstract: OBJECTIVE To introduce the progress of investigation and application for microemulsion-based gels transdermal delivery system. METHODS Reviewed the domestic and international articles, to introduce the prescription screening, preparation, in vitro release, quality checks and the progress of investigation and application for microemulsion-based gels transdermal delivery system. RESULTS Microemulsion-based gels could increase penetration rate, reduce the irritation, extend the drug action time, and use easy. CONCLUSION It is suggested that microemulsion-based gels is a promising carrier for transdermal drug delivery system.