Abstract: OBJECTIVE To observe the preventive effect of Jiangtang Tiaozhiling on T2DM angiopathy and the role of visfatin expression. METHODS Ten health male Wistar rats in normal control group were only fed with standard diet. Fifty health male Wistar rats were fed with high glucose and fat diet+injected STZ intraperitoneal to induce diabetes mellitus. Thirty diabetes mellitus rats were randomly divided into 3 groups: diabetes mellitus model group(n=10, intragastric administration, td NS); Metformin group(n=10, intragastric administration, metformin 200 mg·kg^-1·d^-1) and Jiangtang Tiaozhiling group(n=10, intragastric administration, Jiangtang Tiaozhiling concentrated solution 5 mL·kg^-1·d^-1) and fed with high glucose and fat diet. After 12 weeks, serum glucose, lipids, serum level of monocyte chemotactic factor and intercellular adhesion molecule were checked; the expression of visfatin was detcted by Western-blot method, the aorta thoracalis wall was observed by light microscope and the ultramicrostructural of aorta thoracalis endothelial cell was observed by electron microscope. RESULTS In Jiangtang Tiaozhiling group, the levels of serum glucose, lipids, monocyte chemotactic factor and intercellular adhesion molecule were significant decreased; the expression of visfatin diminished and aorta thoracalis endothelial cell damaged slightly. CONCLUSION Jiangtang Tiaozhiling protects T2DM macroangiopathy, its mechanism may be related to inhibition expression of visfatin and decrease serum glucose, blood lipids level, attenuated inflammatory reaction.