Abstract: OBJECTIVE To synthesize bicalutamide related compound B and determine its physical and chemical properties. METHODS The target compound B was synthesized from N-4-cyano-3-(trifluoromethyl)phenyl-1,2-epoxy-2- methylpropionamide via condensation and oxidation, and its structure was confirmed by ¹H-NMR and ¹³C-NMR, MS, IR, elemental analysis and differential thermal analysis. In addition, some physicochemical properties about compound B, such as solubility in different solvents and melt point, were determined using UV and DSC, respectively. RESULTS The total yield of synthesis route was 74.6% with 99.58% purity. Solubility determination demonstrated that the related compound B had a certain degree of solubility in organic solvent such as alcohol and ketone, but almost insoluble in aqueous media of different pH values. CONCLUSION Bicalutamide related compound B can be easily prepared by mild reaction conditions and simple synthetic method. The physicochemical data obtained in this experiment will provide a useful reference for related research.