Abstract:
OBJECTIVE To perform Meta-analysis of published articles on the efficacy of Bailing capsules for adult patients with primary nephrotic syndrome(PNS) and provide evidence for clinical practice. METHODS We searched Pubmed, CBM, CNKI and other databases to identify eligible articles and extract effect measure-related data to perform Meta-analysis. And qualitative description was also conducted for those unable to be combined. RESULTS Five records were selected. The results of Meta-analysis showed that Bailing capsules could reduce proteinuria SMD=-2.35(-3.72, -0.97), P<0.01 and improve serum albumin SMD=0.94 (0.37, 1.52), P=0.01 in PNS patients. However, Bailing capsules adjuvant therapy had no effect on serum creatinine SMD=-0.50(-1.25, 0.26), P=0.20 and urea nitrogen level SMD=-0.10(-0.36, 0.17), P=0.48. Additionally, two studies reported that Bailing capsules could lower serum cholesterol, triglyceride and low density lipoprotein. CONCLUSION Addition of Bailing capsules could decrease proteinuria and enhance serum albumin in PNS patients. Suggestive evidence showes Bailing capsules adjuvant therapy can correct dyslipidemia in these patients. However, these conclusions should be further validated in future clinical trials.