芪连白术颗粒抗慢性溃疡性结肠炎作用

Effect of Qilianbaizhu Granule on Chronic Ulcerative Colitis

摘要: 目的观察芪连白术颗粒抗慢性溃疡性结肠炎的作用。方法采用右旋葡聚糖硫酸钠(DSS)诱导小鼠形成溃疡性结肠炎模型，观察芪连白术颗粒3个不同剂量对小鼠慢性溃疡性结肠炎的治疗作用。结果与模型组比较，芪连白术颗粒高、中剂量组症状不同程度地明显改善、高剂量组疾病活动指数(DAI)明显降低(P<0.05)；动物的整体状况与结肠炎的病理状况与模型组比较均有明显好转。结论芪连白术颗粒对DSS诱导小鼠慢性溃疡性结肠炎有明显的疗效。

Abstract: OBJECTIVE To observe the effect of Qilianbaizhu granule on chronic ulcerative colitis. METHODS Ulcerative colitis model was established by dextran sodium sulfate(DSS). The effect of Qilianbaizhu granule with 3 different dosages on chronic ulcerative colitis was observed. RESULTS Compared with the model group, Qilianbaizhu granule with high, middle dose group significantly improved symptoms in different degree, DAI of high dose group significantly decreased (P<0.05); the animal's overall situation and colitis pathological condition compared with the model group improved　significantly. CONCLUSION Qilianbaizhu granule has obvious curative effect on chronic ulcerative colitis induced by DSS.