Abstract: OBJECTIVE To study the curative effect of Huanglian Jiangtang tablets on diabetes mellitus. METHODS Euglycermic clamp technique was taken to evaluate the ability of Huanglian Jiangtang tablets to ameliorate insulin resistance on rats modeled with taking high-fat diet with streptozotocin. The effects of Huanglian Jiangtang tablets on reducing serum glucose, serum tricylglycerol and cataract occurrence were investigated on diabetic rats and mice which were modeled with alloxan monohydrate. The effects of Huanglian Jiangtang tablets on the survival time of mice under anoxia and on the phagocytosis of the mice abdominal cavity macrophage were observed. RESULTS Huanglian Jiangtang tablets could ameliorate insulin resistance significantly, reduce serum glucose and serum tricylglycerol, decrease cataract occurrence; prolong the survival time of mice under anoxia and could increase phagocytic index of mice abdominal cavity macrophage. CONCLUSION Huanglian Jiangtang tablets is of great curative value to diabetes mellitus.