Abstract: OBJECTIVE To know the utilization status of three intestinal cleaning agents in clinical practice. METHODS Retrospective analysis of prescriptions with three intestinal cleaning agents was performed from hospital information system in our hospital. Data mining was conducted. Parameters of drug utilization study were calculated and pharmacoeconomic indices were compared by using cost minimization analysis. RESULTS The three drugs were effective without obvious intolerance in clinical use. The DDDs value of product Hengkang Zhengqing ranked first, twice the value of either Shutai Qing or Heshuang. Product Heshuang had the lowest risk of administration errors due to its “all in one” characteristics and also it had the lowest daily expenditure. CONCLUSION Product Heshuang is the most pharmacoeconomic intestinal cleaning agent.