Abstract: OBJECTIVE To study prescription and technique of intragastric floating sandwiched osmotic pump tablets (SOPT) of irbesartan and inspect release property in vitro. METHODS The swelling rate, permeation rate of water, shear viscosity of slow-speed revolution, yield stress and release property was inspected to determine the dosage of the swelling agent, porous agent, suspending agent and osmotic agent. RESULTS The optimization of prescription and technique were definited: swelling agent was a mixture of PEO(Mw 5 000 000) and HPMC as a ratio of 4∶1 (the dosage was 70 mg); osmotic agent sodium chloride was 25 mg; porous agent PEG 400 was 8%; the ratio of suspending agent PEO(Mw 200 000) to irbesartan was 1∶4. The release behavior of SOPT coincidented with zero-level equation well and the character of controlled-release was transparent. CONCLUSION SOPT has good controlled-release in vitro and the release behavior in vivo need to be investigated.