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    盐酸塞利洛尔合成工艺改进

    Improved synthesis of celiprolol hydrochloride

      摘要
    • 摘要: 目的:合成盐酸塞利洛尔,并进行工艺改进。方法:革除溴化反应,对醚化反应进行了优化。结果:使合成路线缩短一步,醚化收率比文献值提高20%以上。结论:该路线较适合于工业化生产。

       

      Abstract: OBJECTIVE: Synthesis of celiprolol hydrochloride and the improvement of the process. METHODS:Abolishing of brominating step and optimizing of etherifying reaction. RESULTS: Synthetic route was shorten by one step, the yield of etherification increased by

       

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